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January 2021; 8 (1) ArticleOpen Access

Chitinase 3–like 1 and neurofilament light chain in CSF and CNS atrophy in MS

Ruth Schneider, Barbara Bellenberg, Barbara Gisevius, Sarah Hirschberg, Roman Sankowski, Marco Prinz, Ralf Gold, Carsten Lukas, Aiden Haghikia
First published November 10, 2020, DOI: https://doi.org/10.1212/NXI.0000000000000906
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  • Figure 1
    Figure 1 CHI3L1 (A) and NfL (B) concentrations in CSF of PMS and RMS

    The 2D plots depict the distribution of the results; the boxes mark the median and interquartile ranges. The 2D plots depict the distribution of the results; the boxes mark the median and interquartile ranges. *p < 0.050, **p < 0.001 in Mann-Whitney U tests. CHI3L1 = chitinase 3–like protein 1; NfL = neurofilament light chain; PMS = progressive MS; RMS = relapsing MS.

  • Figure 2
    Figure 2 Association between (A) CHI3L1 and MUCCA and (B) NfL and BGM

    The line represents simple linear regressions between the variable pairs with R2: coefficient of determination. BGM = brain gray matter; CHI3L1 = chitinase 3–like protein 1; NfL = neurofilament light chain; MUCCA = mean upper cervical cord area.

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