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January 2021; 8 (1) ArticleOpen Access

Time course of dementia following sepsis in German health claims data

Thomas Fritze, View ORCID ProfileGabriele Doblhammer, Catherine N. Widmann, Michael T. Heneka
First published December 8, 2020, DOI: https://doi.org/10.1212/NXI.0000000000000911
Thomas Fritze
From the German Center for Neurodegenerative Diseases (T.F., G.D., C.N.W., M.T.H.), Bonn; Institute for Sociology and Demography (G.D.), University of Rostock; and Department of Neurodegenerative Disease and Geriatric Psychiatry (C.N.W., M.T.H.), University of Bonn, Germany.
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Gabriele Doblhammer
From the German Center for Neurodegenerative Diseases (T.F., G.D., C.N.W., M.T.H.), Bonn; Institute for Sociology and Demography (G.D.), University of Rostock; and Department of Neurodegenerative Disease and Geriatric Psychiatry (C.N.W., M.T.H.), University of Bonn, Germany.
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  • ORCID record for Gabriele Doblhammer
Catherine N. Widmann
From the German Center for Neurodegenerative Diseases (T.F., G.D., C.N.W., M.T.H.), Bonn; Institute for Sociology and Demography (G.D.), University of Rostock; and Department of Neurodegenerative Disease and Geriatric Psychiatry (C.N.W., M.T.H.), University of Bonn, Germany.
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Michael T. Heneka
From the German Center for Neurodegenerative Diseases (T.F., G.D., C.N.W., M.T.H.), Bonn; Institute for Sociology and Demography (G.D.), University of Rostock; and Department of Neurodegenerative Disease and Geriatric Psychiatry (C.N.W., M.T.H.), University of Bonn, Germany.
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Citation
Time course of dementia following sepsis in German health claims data
Thomas Fritze, Gabriele Doblhammer, Catherine N. Widmann, Michael T. Heneka
Neurol Neuroimmunol Neuroinflamm Jan 2021, 8 (1) e911; DOI: 10.1212/NXI.0000000000000911

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    Figure 1 Dementia incidence rates by time since the latest sepsis diagnosis, ICU stay, surgery, and delirium diagnosis (N = 161,567)

    Source: Health claims data AOK 2004–2015; 95% CIs. AOK = Allgemeine Ortskrankenkasse; ICU = intensive care unit.

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    Figure 2 Dementia incidence rates by time since sepsis diagnosis and age

    Source: Health claims data AOK 2004–2015; 95% CIs. AOK = Allgemeine Ortskrankenkasse; ICU = intensive care unit.

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    Figure 3 Kaplan-Meier survival analysis for cases and controls

    Zero signifies date of sepsis before censoring for cases and index date for controls (N = 14,188). Source: Health claims data AOK 2004–2015; nno sepsis = 7,094 nsepsis, no ICU = 5,318 nsepsis, ICU = 1,776. AOK = Allgemeine Ortskrankenkasse; ICU = intensive care unit.

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