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January 2021; 8 (1) ArticleOpen Access

Overweight/obesity in young adulthood interacts with aspects of EBV infection in MS etiology

View ORCID ProfileAnna Karin Hedström, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Tomas Olsson, View ORCID ProfileLars Alfredsson
First published December 15, 2020, DOI: https://doi.org/10.1212/NXI.0000000000000912
Anna Karin Hedström
From the Department of Clinical Neuroscience (A.K.H., J.H., T.O., L.A.), Karolinska Institutet, Stockholm, Sweden; Infections and Cancer Epidemiology (N.B., J.B., T.W.), German Cancer Research Center (DKFZ), Heidelberg; Center for Molecular Medicine (J.H., T.O.), Karolinska Institutet at Karolinska University Hospital, Solna, Sweden; and Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm, Sweden.
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  • ORCID record for Anna Karin Hedström
Nicole Brenner
From the Department of Clinical Neuroscience (A.K.H., J.H., T.O., L.A.), Karolinska Institutet, Stockholm, Sweden; Infections and Cancer Epidemiology (N.B., J.B., T.W.), German Cancer Research Center (DKFZ), Heidelberg; Center for Molecular Medicine (J.H., T.O.), Karolinska Institutet at Karolinska University Hospital, Solna, Sweden; and Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm, Sweden.
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  • For correspondence: nicole.brenner@dkfz-heidelberg.de
Julia Butt
From the Department of Clinical Neuroscience (A.K.H., J.H., T.O., L.A.), Karolinska Institutet, Stockholm, Sweden; Infections and Cancer Epidemiology (N.B., J.B., T.W.), German Cancer Research Center (DKFZ), Heidelberg; Center for Molecular Medicine (J.H., T.O.), Karolinska Institutet at Karolinska University Hospital, Solna, Sweden; and Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm, Sweden.
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  • For correspondence: j.butt@dkfz-heidelberg.de
Jan Hillert
From the Department of Clinical Neuroscience (A.K.H., J.H., T.O., L.A.), Karolinska Institutet, Stockholm, Sweden; Infections and Cancer Epidemiology (N.B., J.B., T.W.), German Cancer Research Center (DKFZ), Heidelberg; Center for Molecular Medicine (J.H., T.O.), Karolinska Institutet at Karolinska University Hospital, Solna, Sweden; and Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm, Sweden.
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  • For correspondence: jan.hillert@ki.se
Tim Waterboer
From the Department of Clinical Neuroscience (A.K.H., J.H., T.O., L.A.), Karolinska Institutet, Stockholm, Sweden; Infections and Cancer Epidemiology (N.B., J.B., T.W.), German Cancer Research Center (DKFZ), Heidelberg; Center for Molecular Medicine (J.H., T.O.), Karolinska Institutet at Karolinska University Hospital, Solna, Sweden; and Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm, Sweden.
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  • For correspondence: t.waterboer@dkfz-heidelberg.de
Tomas Olsson
From the Department of Clinical Neuroscience (A.K.H., J.H., T.O., L.A.), Karolinska Institutet, Stockholm, Sweden; Infections and Cancer Epidemiology (N.B., J.B., T.W.), German Cancer Research Center (DKFZ), Heidelberg; Center for Molecular Medicine (J.H., T.O.), Karolinska Institutet at Karolinska University Hospital, Solna, Sweden; and Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm, Sweden.
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  • For correspondence: tomas.olsson@ki.se
Lars Alfredsson
From the Department of Clinical Neuroscience (A.K.H., J.H., T.O., L.A.), Karolinska Institutet, Stockholm, Sweden; Infections and Cancer Epidemiology (N.B., J.B., T.W.), German Cancer Research Center (DKFZ), Heidelberg; Center for Molecular Medicine (J.H., T.O.), Karolinska Institutet at Karolinska University Hospital, Solna, Sweden; and Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm, Sweden.
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  • For correspondence: lars.alfredsson@ki.se
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Citation
Overweight/obesity in young adulthood interacts with aspects of EBV infection in MS etiology
Anna Karin Hedström, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Tomas Olsson, Lars Alfredsson
Neurol Neuroimmunol Neuroinflamm Jan 2021, 8 (1) e912; DOI: 10.1212/NXI.0000000000000912

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    Figure OR of developing MS for subjects with different combinations of DRB1*15:01, overweight/obesity (>25 kg/m2), and IM history and EBNA-1 status, respectively, compared with unexposed DRB1*15:01-negative subjects

    Based on data from tables 4 and 5.

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