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March 2021; 8 (2) Clinical/Scientific NotesOpen Access

Evidence for Independent Hepatitis E Virus Replication in the Brain

View ORCID ProfileEvert P.M. den Drijver, Annemarie E. Brouwer, Nathalie E. Synhaeve, Janneke P. Keijer, Jaco J. Verweij, View ORCID ProfileJean-Luc Murk, Suzan D. Pas
First published January 5, 2021, DOI: https://doi.org/10.1212/NXI.0000000000000939
Evert P.M. den Drijver
From the Microvida (E.P.M.d.D., J.J.V., J.-L.M.), Department of Internal Medicine (A.E.B.), and Department of Neurology (N.E.S.), Elisabeth-TweeSteden Hospital, Tilburg; and Microvida (J.P.K., S.D.P.), Bravis Hospital, Roosendaal, The Netherlands.
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  • ORCID record for Evert P.M. den Drijver
Annemarie E. Brouwer
From the Microvida (E.P.M.d.D., J.J.V., J.-L.M.), Department of Internal Medicine (A.E.B.), and Department of Neurology (N.E.S.), Elisabeth-TweeSteden Hospital, Tilburg; and Microvida (J.P.K., S.D.P.), Bravis Hospital, Roosendaal, The Netherlands.
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  • For correspondence: annemarie.brouwer@etz.nl
Nathalie E. Synhaeve
From the Microvida (E.P.M.d.D., J.J.V., J.-L.M.), Department of Internal Medicine (A.E.B.), and Department of Neurology (N.E.S.), Elisabeth-TweeSteden Hospital, Tilburg; and Microvida (J.P.K., S.D.P.), Bravis Hospital, Roosendaal, The Netherlands.
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  • For correspondence: n.synhaeve@etz.nl
Janneke P. Keijer
From the Microvida (E.P.M.d.D., J.J.V., J.-L.M.), Department of Internal Medicine (A.E.B.), and Department of Neurology (N.E.S.), Elisabeth-TweeSteden Hospital, Tilburg; and Microvida (J.P.K., S.D.P.), Bravis Hospital, Roosendaal, The Netherlands.
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  • For correspondence: janneke.keijer@gmail.com
Jaco J. Verweij
From the Microvida (E.P.M.d.D., J.J.V., J.-L.M.), Department of Internal Medicine (A.E.B.), and Department of Neurology (N.E.S.), Elisabeth-TweeSteden Hospital, Tilburg; and Microvida (J.P.K., S.D.P.), Bravis Hospital, Roosendaal, The Netherlands.
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  • For correspondence: j.verweij@etz.nl
Jean-Luc Murk
From the Microvida (E.P.M.d.D., J.J.V., J.-L.M.), Department of Internal Medicine (A.E.B.), and Department of Neurology (N.E.S.), Elisabeth-TweeSteden Hospital, Tilburg; and Microvida (J.P.K., S.D.P.), Bravis Hospital, Roosendaal, The Netherlands.
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  • ORCID record for Jean-Luc Murk
  • For correspondence: j.murk@etz.nl
Suzan D. Pas
From the Microvida (E.P.M.d.D., J.J.V., J.-L.M.), Department of Internal Medicine (A.E.B.), and Department of Neurology (N.E.S.), Elisabeth-TweeSteden Hospital, Tilburg; and Microvida (J.P.K., S.D.P.), Bravis Hospital, Roosendaal, The Netherlands.
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Full PDF
Citation
Evidence for Independent Hepatitis E Virus Replication in the Brain
Evert P.M. den Drijver, Annemarie E. Brouwer, Nathalie E. Synhaeve, Janneke P. Keijer, Jaco J. Verweij, Jean-Luc Murk, Suzan D. Pas
Neurol Neuroimmunol Neuroinflamm Mar 2021, 8 (2) e939; DOI: 10.1212/NXI.0000000000000939

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Article Information

vol. 8 no. 2 e939
DOI: 
https://doi.org/10.1212/NXI.0000000000000939
PubMed: 
33402526

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received June 23, 2020
  • Accepted in final form November 9, 2020
  • First Published January 5, 2021.

Copyright & Usage: 
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Evert P.M. den Drijver, MD,
    2. Annemarie E. Brouwer, MD, PhD (annemarie.brouwer{at}etz.nl),
    3. Nathalie E. Synhaeve, MD, PhD (n.synhaeve{at}etz.nl),
    4. Janneke P. Keijer, MSc (janneke.keijer{at}gmail.com),
    5. Jaco J. Verweij, PhD (j.verweij{at}etz.nl),
    6. Jean-Luc Murk, MD, PhD (j.murk{at}etz.nl) and
    7. Suzan D. Pas, PhD (s.pas{at}bravis.nl)
  1. Evert P.M. den Drijver, MD,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Annemarie E. Brouwer, MD, PhD (annemarie.brouwer{at}etz.nl),
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Nathalie E. Synhaeve, MD, PhD (n.synhaeve{at}etz.nl),
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Janneke P. Keijer, MSc (janneke.keijer{at}gmail.com),
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Jaco J. Verweij, PhD (j.verweij{at}etz.nl),
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Jean-Luc Murk, MD, PhD (j.murk{at}etz.nl) and
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other activities:
    1. Financial compensation for educational events of Biogen and Teva (commercial entities), paid to department.

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Suzan D. Pas, PhD (s.pas{at}bravis.nl)
  14. Scientific Advisory Boards:
    1. (1) Luminex Corp.

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Microvida (E.P.M.d.D., J.J.V., J.-L.M.), Department of Internal Medicine (A.E.B.), and Department of Neurology (N.E.S.), Elisabeth-TweeSteden Hospital, Tilburg; and Microvida (J.P.K., S.D.P.), Bravis Hospital, Roosendaal, The Netherlands.
  1. Correspondence
    Dr. den Drijver evertdendrijver{at}gmail.com
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