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March 2021; 8 (2) Clinical/Scientific NotesOpen Access

Presence of SARS-CoV-2 Transcripts in the Choroid Plexus of MS and Non-MS Patients With COVID-19

View ORCID ProfileVidmante Fuchs, View ORCID ProfileMichael Kutza, View ORCID ProfileSven Wischnewski, View ORCID ProfileNikolaus Deigendesch, Luc Lutz, Laila Kulsvehagen, Gerda Ricken, Ludwig Kappos, View ORCID ProfileAlexandar Tzankov, Simon Hametner, Stephan Frank, View ORCID ProfileLucas Schirmer, View ORCID ProfileAnne-Katrin Pröbstel
First published January 27, 2021, DOI: https://doi.org/10.1212/NXI.0000000000000957
Vidmante Fuchs
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • ORCID record for Vidmante Fuchs
  • For correspondence: vidmante.fuchs@unibas.ch
Michael Kutza
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • ORCID record for Michael Kutza
  • For correspondence: vidmante.fuchs@unibas.ch
Sven Wischnewski
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • ORCID record for Sven Wischnewski
  • For correspondence: s.wischnewski@stud.uni-heidelberg.de
Nikolaus Deigendesch
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • ORCID record for Nikolaus Deigendesch
  • For correspondence: nikolaus.deigendesch@usb.ch
Luc Lutz
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • For correspondence: luc.lutz@unibas.ch
Laila Kulsvehagen
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • For correspondence: laila.kulsvehagen@unibas.ch
Gerda Ricken
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • For correspondence: gerda.ricken@meduniwien.ac.at
Ludwig Kappos
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • For correspondence: ludwig.kappos@usb.ch
Alexandar Tzankov
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • ORCID record for Alexandar Tzankov
  • For correspondence: alexandar.tzankov@usb.ch
Simon Hametner
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • For correspondence: simon.hametner@meduniwien.ac.at
Stephan Frank
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • For correspondence: stephan.frank@usb.ch
Lucas Schirmer
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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  • ORCID record for Lucas Schirmer
  • For correspondence: lucas.schirmer@medma.uni-heidelberg.de
Anne-Katrin Pröbstel
From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
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Full PDF
Citation
Presence of SARS-CoV-2 Transcripts in the Choroid Plexus of MS and Non-MS Patients With COVID-19
Vidmante Fuchs, Michael Kutza, Sven Wischnewski, Nikolaus Deigendesch, Luc Lutz, Laila Kulsvehagen, Gerda Ricken, Ludwig Kappos, Alexandar Tzankov, Simon Hametner, Stephan Frank, Lucas Schirmer, Anne-Katrin Pröbstel
Neurol Neuroimmunol Neuroinflamm Mar 2021, 8 (2) e957; DOI: 10.1212/NXI.0000000000000957

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Article Information

vol. 8 no. 2 e957
DOI: 
https://doi.org/10.1212/NXI.0000000000000957
PubMed: 
33504636

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received September 7, 2020
  • Accepted in final form November 19, 2020
  • First Published January 27, 2021.

Copyright & Usage: 
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Vidmante Fuchs, BSc* (vidmante.fuchs@unibas.ch),
    2. Michael Kutza, Cand Med* (vidmante.fuchs@unibas.ch),
    3. Sven Wischnewski, Cand Med* (s.wischnewski@stud.uni-heidelberg.de),
    4. Nikolaus Deigendesch, MD, PhD (nikolaus.deigendesch@usb.ch),
    5. Luc Lutz, BSc (luc.lutz@unibas.ch),
    6. Laila Kulsvehagen, MSc (laila.kulsvehagen@unibas.ch),
    7. Gerda Ricken, MSc (gerda.ricken@meduniwien.ac.at),
    8. Ludwig Kappos, MD (ludwig.kappos@usb.ch),
    9. Alexandar Tzankov, MD (alexandar.tzankov@usb.ch),
    10. Simon Hametner, MD, PhD (simon.hametner@meduniwien.ac.at),
    11. Stephan Frank, MD (stephan.frank@usb.ch),
    12. Lucas Schirmer, MD*,† (lucas.schirmer@medma.uni-heidelberg.de) and
    13. Anne-Katrin Pröbstel, MD*,†
  1. Vidmante Fuchs, BSc* (vidmante.fuchs@unibas.ch),
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Michael Kutza, Cand Med* (vidmante.fuchs@unibas.ch),
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Sven Wischnewski, Cand Med* (s.wischnewski@stud.uni-heidelberg.de),
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Nikolaus Deigendesch, MD, PhD (nikolaus.deigendesch@usb.ch),
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Luc Lutz, BSc (luc.lutz@unibas.ch),
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Laila Kulsvehagen, MSc (laila.kulsvehagen@unibas.ch),
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Gerda Ricken, MSc (gerda.ricken@meduniwien.ac.at),
  14. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  15. Ludwig Kappos, MD (ludwig.kappos@usb.ch),
  16. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. (1)Multiple Sclerosis and Related Disorders member of the Editorial Board

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. (1)Actelion, (2)Allmirall, (3)Bayer, (4) Baxalta, (5)Biogen, (6) CSL Behring,(7)Excemed, (8)Desitin,(9) Eisai,(10) Genzyme, (11) Japan Tobacco, (12)Merck,(13) Minoryx, (14)Novartis, (15)Pfizer,(16)Receptos/Celgene, (17)Roche,(18)sanofi-aventis,(19)Santhera,(20)Teva,

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. (1)the Swiss MS Society, (2)the Swiss National Research Foundation, (3)the European Union, (4)Roche Research Foundations, (5) Innosuisse

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License fee payments, Technology or Inventions:
    1. (1) license fees for Neurostatus products paid directly to University Hospital Basel

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  17. Alexandar Tzankov, MD (alexandar.tzankov@usb.ch),
  18. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Pathobiology, editorial board member, 4 years

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Botnar Research Centre for Child Health (BRCCH)

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  19. Simon Hametner, MD, PhD (simon.hametner@meduniwien.ac.at),
  20. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. Sanofi Genzyme, Speaker honoraria

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  21. Stephan Frank, MD (stephan.frank@usb.ch),
  22. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE …

  23. Lucas Schirmer, MD*,† (lucas.schirmer@medma.uni-heidelberg.de) and
  24. Anne-Katrin Pröbstel, MD*,†
  1. From the Multiple Sclerosis Center (V.F., L.L., L. Kulsvehagen, L. Kappos), Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital and University of Basel, Switzerland; Department of Neurology (M.K., S.W., L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; Pathology (N.D., A.T., S.F.), Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (G.R., S.H.), Division of Neuropathology and Neurochemistry, Medical University Vienna, Austria; Mannheim Center for Translational Neuroscience and Institute for Innate Immunoscience (L.S.), Medical Faculty Mannheim, Heidelberg University, Germany; and Interdisciplinary Center for Neurosciences (L.S.), Heidelberg University, Germany.
  1. Correspondence
    Dr. Pröbstel anne-katrin.proebstel{at}usb.ch
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