Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology: Neuroimmunology & Neuroinflammation COVID-19 Article Hub
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology: Neuroimmunology & Neuroinflammation COVID-19 Article Hub
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center
  • Home
  • Articles
  • Issues
  • COVID-19 Article Hub
  • Infographics & Video Summaries

User menu

  • My Alerts
  • Log in

Search

  • Advanced search
Neurology Neuroimmunology & Neuroinflammation
Home
A peer-reviewed clinical and translational neurology open access journal
  • My Alerts
  • Log in
Site Logo
  • Home
  • Articles
  • Issues
  • COVID-19 Article Hub
  • Infographics & Video Summaries

Share

March 2021; 8 (2) ArticleOpen Access

Defining Benign/Burnt-Out MS and Discontinuing Disease-Modifying Therapies

Derek McFaul, Nektar N. Hakopian, Jessica B. Smith, Allen Scott Nielsen, Annette Langer-Gould
First published February 8, 2021, DOI: https://doi.org/10.1212/NXI.0000000000000960
Derek McFaul
From the Department of Neurology (D.M., A.L.-G.), Los Angeles Medical Center, Southern California Permanente Medical Group; Department of Drug Use Management, Los Angeles Medical Center, Kaiser Permanente (N.N.H.); Department of Research & Evaluation (J.B.S.), Southern California Permanente Medical Group, Pasadena; and Department of Neurology (A.S.N.), Fontana Medical Center, Southern California Permanente Medical Group.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: derek.j.mcfaul@kp.org
Nektar N. Hakopian
From the Department of Neurology (D.M., A.L.-G.), Los Angeles Medical Center, Southern California Permanente Medical Group; Department of Drug Use Management, Los Angeles Medical Center, Kaiser Permanente (N.N.H.); Department of Research & Evaluation (J.B.S.), Southern California Permanente Medical Group, Pasadena; and Department of Neurology (A.S.N.), Fontana Medical Center, Southern California Permanente Medical Group.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: nektar.n.hakopian@kp.org
Jessica B. Smith
From the Department of Neurology (D.M., A.L.-G.), Los Angeles Medical Center, Southern California Permanente Medical Group; Department of Drug Use Management, Los Angeles Medical Center, Kaiser Permanente (N.N.H.); Department of Research & Evaluation (J.B.S.), Southern California Permanente Medical Group, Pasadena; and Department of Neurology (A.S.N.), Fontana Medical Center, Southern California Permanente Medical Group.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: jessica.b.smith@kp.org
Allen Scott Nielsen
From the Department of Neurology (D.M., A.L.-G.), Los Angeles Medical Center, Southern California Permanente Medical Group; Department of Drug Use Management, Los Angeles Medical Center, Kaiser Permanente (N.N.H.); Department of Research & Evaluation (J.B.S.), Southern California Permanente Medical Group, Pasadena; and Department of Neurology (A.S.N.), Fontana Medical Center, Southern California Permanente Medical Group.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: a.s.nielsen@kp.org
Annette Langer-Gould
From the Department of Neurology (D.M., A.L.-G.), Los Angeles Medical Center, Southern California Permanente Medical Group; Department of Drug Use Management, Los Angeles Medical Center, Kaiser Permanente (N.N.H.); Department of Research & Evaluation (J.B.S.), Southern California Permanente Medical Group, Pasadena; and Department of Neurology (A.S.N.), Fontana Medical Center, Southern California Permanente Medical Group.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Defining Benign/Burnt-Out MS and Discontinuing Disease-Modifying Therapies
Derek McFaul, Nektar N. Hakopian, Jessica B. Smith, Allen Scott Nielsen, Annette Langer-Gould
Neurol Neuroimmunol Neuroinflamm Mar 2021, 8 (2) e960; DOI: 10.1212/NXI.0000000000000960

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
1074

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

Article Figures & Data

Figures

  • Tables
  • Figure 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1 Study Inclusion and Outcomes Following DMT Discontinuation in Benign/Burnt-Out MS

    Depicted is the study inclusion flowchart and post-DMT discontinuation outcomes among the patients with MS with a suspected benign/burnt-out disease course at the time of DMT discontinuation. Of the 475 KPSC members whose last dispensed MS DMT was between 2012 and 2016, and who were 50 years or older at the time of last dispensed DMT, 136 had a suspected benign/burnt-out disease course at DMT discontinuation. Of these, only 5 experienced a relapse following DMT discontinuation, of which only 2 resulted in new, albeit mild, residual deficits. *Asymptomatic MRI disease activity was defined according to the MAGNIMS criteria16 to avoid misclassification of microvascular ischemic changes as MS disease activity. DMT = disease-modifying therapy; dz = disease; KPSC = Kaiser Permanente Southern California; RRMS = relapsing-remitting MS; SPMS = secondary progressive MS.

Tables

  • Figures
  • Table 1
  • Table 2
  • Table3

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • Glossary
    • Methods
    • Results
    • Discussion
    • Study Funding
    • Disclosure
    • Acknowledgment
    • Appendix Authors
    • Footnotes
    • References
  • Figures & Data
  • Info & Disclosures
Advertisement

Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke: A Post Hoc Analysis of the EXTEND-IA TNK Trials

Dr. Nicole Sur and Dr. Mausaminben Hathidara

► Watch

Related Articles

  • No related articles found.

Topics Discussed

  • Autoimmune diseases
  • Multiple sclerosis
  • Cohort studies

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Views & Reviews
    Comment on 2018 American Academy of Neurology guidelines on disease-modifying therapies in MS
    John R. Corboy, Brian G. Weinshenker, Dean M. Wingerchuk et al.
    Neurology, April 23, 2018
  • Review
    Secondary Progressive Multiple Sclerosis
    New Insights
    Bruce A.C. Cree, Douglas L. Arnold, Jeremy Chataway et al.
    Neurology, June 04, 2021
  • Articles
    Clinical and laboratory features of primary progressive and secondary progressive MS
    Khurram Bashir, John N. Whitaker et al.
    Neurology, September 01, 1999
  • Article
    MRI activity in MS and completed pregnancy
    Data from a tertiary academic center
    Maria Houtchens, Riley Bove, Brian Healy et al.
    Neurology: Neuroimmunology & Neuroinflammation, September 11, 2020
Neurology - Neuroimmunology Neuroinflammation: 10 (4)

Articles

  • Articles
  • Issues
  • Popular Articles

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology: Neuroimmunology & Neuroinflammation
Online ISSN: 2332-7812

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise