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May 2021; 8 (3) ArticleOpen Access

Demyelinating Events Following Initiation of Anti-TNFα Therapy in the British Society for Rheumatology Biologics Registry in Rheumatoid Arthritis

Thomas R.P. Taylor, James Galloway, Rebecca Davies, Kimme Hyrich, Ruth Dobson
First published April 16, 2021, DOI: https://doi.org/10.1212/NXI.0000000000000992
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Article Information

vol. 8 no. 3 e992
DOI: 
https://doi.org/10.1212/NXI.0000000000000992
PubMed: 
33863839
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received January 5, 2021
  • Accepted in final form February 22, 2021
  • First Published April 16, 2021.
Copyright & Usage: 
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Thomas R.P. Taylor, MBChB (thomasrptaylor{at}gmail.com),
    2. James Galloway, MRCP, PhD,
    3. Rebecca Davies, MSc (rdatherapy{at}gmail.com),
    4. Kimme Hyrich, FRCPC, PhD (kimme.hyrich{at}manchester.ac.uk) and
    5. Ruth Dobson, MRCP, PhD
  1. Thomas R.P. Taylor, MBChB (thomasrptaylor{at}gmail.com),
    2. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Non-profit entity: Isaac Schapera Trust research grant to support academic research for academic foundation doctors - 00A31000.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. James Galloway, MRCP, PhD,
    3. Scientific Advisory Boards:

    1. (1) Imperial College London, DSMB chair for trial studying biologic therapies in COVID (non-commercial study) (2) Abbvie, SAB (3) Gilead, SAB (4) Sanofi, SAB

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Abbvie, speaker fees (2) Chugai, speaker fees (3) Celgene, speaker fees (4) Gilead, speaker fees (5) Janssen, speaker fees (6) Lilly, speaker fees (7) Novartis, speaker fees (8) Pfizer, speaker fees (9) Roche, speaker fees (10) Sobi, speaker fees (11) UCB, speaker fees

    Editorial Boards:

    1. (1) Rheumatology, Deputy editor, >10 years (2) Journal of Rheumatology, Editorial advisory board, 1 year

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Rebecca Davies, MSc (rdatherapy{at}gmail.com),
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Kimme Hyrich, FRCPC, PhD (kimme.hyrich{at}manchester.ac.uk) and
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Abbvie - speaker's fees

    Editorial Boards:

    1. Guest editor for Rheumatology supplement on Real World Data 2019; Associate Editor - Annals of Rheumatic Diseases (2020-) Not compensated.

    Patents:

    1. NONE

    Publishing Royalties:

    1. UptoDate - Anti-TNF and Malignancy (2018-)

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. BMS - research support unrelated to the current study Pfizer - research support unrelated to the current study

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. British Society for Rheumatology - research support for the BSRBR-RA database (paid to my university). Versus Arthritis (Grant code 21755) - research support for the Centre for Epidemiology (paid to my university)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Ruth Dobson, MRCP, PhD
    6. Scientific Advisory Boards:

    1. (1) Merck advisory board (2) Biogen advisory board (3) Roche advisory board (4) Roche steering committee

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Biogen Idec, speaker honoraria (2) Teva, speaker honoraria (3) Neurology Academy, speaker honoraria (4) Sanofi Genzyme, attendance at educational meeting (5) Northern Connections MS meeting, speaker honoraria (6) Janssen, speaker honoraria (7) Merck, speaker honoraria

    Editorial Boards:

    1. (1) Frontiers in Neurology - guest editor 2021

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Biogen (2) Merck (3) Celgene

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. (1) Department of Brain Sciences, Imperial College London

    Research Support, Foundations and Societies:

    1. (1) I am currently funded by a grant from Barts Charity (2) Current funding from MS Society of Great Britain and Northern Ireland (3) Current funding from Horne Family Trust (4) MS Society of Great Britain and Northern Ireland/Association of British Neurologists funded my previous position as a Clinical Research Fellow

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Preventive Neurology Unit (T.R.P.T., K.H., R. Dobson), Wolfson Institute of Preventive Medicine, Queen Mary University of London, London; Centre for Rheumatic Diseases (J.G.), King's College London; Centre for Epidemiology Versus Arthritis (R. Davies, K.H.), The University of Manchester, Manchester Academic Health Science Centre, Manchester; National Institute of Health Research Manchester Biomedical Research Centre (K.H.), Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester; and Department of Neurology (R. Dobson), Royal London Hospital, Barts Health NHS Trust, London, United Kingdom.
  1. Correspondence
    Dr. Dobson ruth.dobson{at}qmul.ac.uk

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Article usage: April 2021 to November 2023

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