Article Figures & Data
Figures
- Figure 1 Main Functional and Structural Networks of Interest Related to Sensory, Motor, and High-Order Integrative Functions in Patients With Multiple Sclerosis (MS) and Healthy Controls (HCs)
Spatial maps of relevant (A) resting-state (RS) functional connectivity (FC) and (B) gray matter (GM) networks. RS FC networks were thresholded at p < 0.05, with family-wise error corrected (positive effects of interest from the 2-sample t test). GM structural networks were selected by visual inspection and spatial matching with RS FC networks, and as in previous studies,23 they were displayed using a threshold z-score >2.
- Figure 2 Between-Group Comparison of Functional and Structural Networks Between HC and MS
(A) Voxel-wise between-group comparisons of RS FC: the blue–light blue color scale shows decreased RS FC in MS vs HC, whereas the red-yellow color scale shows increased RS FC in MS vs HC (age- and sex-adjusted 2-sample t test, p < 0.001 uncorrected for illustrative purposes). (B) Boxplots showing average loading coefficients (means and SDs) of relevant GM networks. MS = multiple sclerosis; FC = functional connectivity; GM = gray matter; HC = healthy controls.
- Figure 3 Analysis of Prediction
Results of the ROC analysis showing the area under the curve (OOB AUC) of random forest models predicting clinical disability worsening (A) and conversion to SPMS (B). Models show the increments of AUC associated with the inclusion of conventional MRI variables (green lines) and network MRI variables (orange lines) in addition to confounding covariates and clinical variables (purple lines). AUC = area under the curve; OOB = out-of-bag; ROC = receiver operating characteristic; SPMS = secondary progressive multiple sclerosis.
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