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Figures
- Figure MRI and CSF Measured JC Virus Load Before During and After BK Virus-Specific T-Cell Therapy in Patient 1 (A and B) and Patient 2 (C and D)
(A) Axial FLAIR sections on multiple time points before and during BKV-CTL therapy. Increasing PML lesions in the first 3 months. Stagnation/slight regression of lesions from the fourth month on. BKV-CTL therapy had been implemented at third month. Red arrow: month of PML diagnosis since symptom onset by the detection of JCPyV DNA in CSF. (B) JC virus load (c/mL) before, during, and after BKV-CTL therapy measured in patient's CSF. x-axis: days since diagnosis; y-axis: c/mL JC virus; and green arrows: infusions of BKV-CTL. (C) Axial T2-weighted (top row) and contrast-enhanced T1-weighted (bottom row) sections on multiple time points before and during BKV-CTL therapy. Increasing PML lesions in the first 2 months. Regression of lesions from the second month on. In addition, regression of the contrast enhancement could be observed. BKV-CTL therapy had been implemented at first month. Red arrow: month of PML diagnosis since symptom onset by the detection of JCPyV DNA in CSF. (D) JC virus load (c/mL) before, during, and after BKV-CTL therapy measured in patient's CSF. x-axis: days since diagnosis; y-axis c/mL JC virus; and green arrows: infusions of BKV-CTL. BKV-CTL = BK virus-specific T cell; JCPyV = JC polyomavirus; PML = progressive multifocal leukoencephalopathy.
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