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September 2021; 8 (5) ArticleOpen Access

Antiplexin D1 Antibodies Relate to Small Fiber Neuropathy and Induce Neuropathic Pain in Animals

Takayuki Fujii, Eun-Jae Lee, Yukino Miyachi, Ryo Yamasaki, Young-Min Lim, Kyoko Iinuma, Ayako Sakoda, Kwang-Kuk Kim, Jun-ichi Kira
First published June 7, 2021, DOI: https://doi.org/10.1212/NXI.0000000000001028
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Article Information

vol. 8 no. 5 e1028
DOI: 
https://doi.org/10.1212/NXI.0000000000001028
PubMed: 
34099459
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received December 3, 2020
  • Accepted in final form April 5, 2021
  • First Published June 7, 2021.
Copyright & Usage: 
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Takayuki Fujii, MD, PhD (takayuki{at}neuro.med.kyushu-u.ac.jp),
    2. Eun-Jae Lee, MD, PhD (siverash{at}gmail.com),
    3. Yukino Miyachi, MSc (ykno.m.223{at}gmail.com),
    4. Ryo Yamasaki, MD, PhD (ryoya{at}neuro.med.kyushu-u.ac.jp),
    5. Young-Min Lim, MD, PhD (limy{at}amc.seoul.kr),
    6. Kyoko Iinuma, MSc (kyoiinuma{at}gmail.com),
    7. Ayako Sakoda, MD, PhD (sakoda-a{at}neuro.med.kyushu-u.ac.jp),
    8. Kwang-Kuk Kim, MD, PhD (kkim601{at}gmail.com) and
    9. Jun-ichi Kira, MD, PhD
  1. Takayuki Fujii, MD, PhD (takayuki{at}neuro.med.kyushu-u.ac.jp),
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1)Takeda Pharmaceutical Company, speaker honoraria (2)Eisai, speaker honoraria

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Mitsubishi Tanabe Pharma, (2) Osoegawa Neurology Clinic, (3) Bayer Yakuhin, Ltd., (4) the Japan Blood Products Organization

    Research Support, Government Entities:

    1. (1) the Japan Society for the Promotion of Science (JSPS) KAKENHI, grant number JP19K17037, principal investigator, 2019-2020

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Eun-Jae Lee, MD, PhD (siverash{at}gmail.com),
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Ministry of Science and ICT, South Korea (NRF- 2018R1C1B6008884, NRF-2018M3A9E8066249), Ministry of Health & Welfare, South Korea (HI18C2383)

    Research Support, Academic Entities:

    1. Asan Institute for Life Science (2019-0830, 2019-0851), Asan Medical Center, Seoul, South Korea

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Yukino Miyachi, MSc (ykno.m.223{at}gmail.com),
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Ryo Yamasaki, MD, PhD (ryoya{at}neuro.med.kyushu-u.ac.jp),
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Clinical and experimental neuroimmunology, managing editor, since 2016 until now

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Young-Min Lim, MD, PhD (limy{at}amc.seoul.kr),
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Kyoko Iinuma, MSc (kyoiinuma{at}gmail.com),
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Ayako Sakoda, MD, PhD (sakoda-a{at}neuro.med.kyushu-u.ac.jp),
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Kwang-Kuk Kim, MD, PhD (kkim601{at}gmail.com) and
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Jun-ichi Kira, MD, PhD
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. JK received speaking fees and/or honoraria from (1) Novartis Pharma, (2) Mitsubishi Tanabe Pharma, (3) Boehringer Ingelheim, (4) Teijin Pharma, (5) the Takeda Pharmaceutical Company, (6) Otsuka Pharmaceutical, (7) Astellas Pharma, (8) Pfizer Japan, and (9) Eisai.

    Editorial Boards:

    1. (1) Multiple Sclerosis Journal, Editorial Board Member, 2006-, (2) BMC Medicine, Editorial Board Member, 2010-, (3) Journal of the Neurological Sciences, Editorial Board Member, 2010-, (4) Multiple Sclerosis and Related Disorders, Editorial Board Member, Section Editor, 2011-, (5) PLOS ONE, Editorial Board Member, 2011-, (6) Frontiers in Immunology, Associate Editor, 2017-

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Biogen Japan (consultancy, since 2009)

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Novartis Pharma, (2) Boehringer Ingelheim, (3) Teijin Pharma, (4) Takeda Pharmaceutical Company, (5) Otsuka Pharmaceutical, (6) Astellas Pharma, (7) Pfizer Japan, (8) Eisai, (9) Dainippon-Sumitomo Pharmaceutical, (10) Tanabe-Mitsubishi Pharmaceutical, (11) Japan Blood Products Organization, (12) Bayer, (13) Yamasa corporation

    Research Support, Government Entities:

    1. (1) Grant-in-Aid for Scientific Research on Innovative Areas (MEXT KAKENHI), 25117012, Principal Investigator, 2013-2018, (2) Grant-in-Aid for Scientific Research on Innovative Areas (MEXT KAKENHI), 25117001, Co- investigator, 2013-2018, (3) Grant-in-Aid for Scientific Research on Innovative Areas (MEXT KAKENHI), 15K21729, Co-investigator, 2015-2018, (4) Grant-in-Aid for Challenging Exploratory Research (JSPS KAKENHI), 15K15341, Principal Investigator, 2015-2017, (5) Grant-in-Aid for Scientific Research (C) (JSPS KAKENHI), 15K09343, Co- investigator, 2015-2018, (6) Grant-in-Aid for Scientific Research (C) (JSPS KAKENHI), 16K10727, Co- investigator, 2016-2019, (7) Grant-in-Aid for Scientific Research (A) (JSPS KAKENHI), 16H02657, Principal Investigator, 2016-2019, (8) Grant-in-Aid for Challenging Exploratory Research (JSPS KAKENHI), 17K19663, Principal Investigator, 2017-2019, (9) Grant-in-Aid for Scientific Research (C) (JSPS KAKENHI), 18K07529, Co- investigator, 2018-2021, (10) Grant-in-Aid for Scientific Research (A) (JSPS KAKENHI), 19H01045, Principal Investigator, 2019-2022, (11) Practical Research Project for Rare/Intractable Diseases" from Japan Agency for Medical Research and Development, AMED, Japan, 16ek0109039h0003, Principal Investigator, 2016-2017, (12) Practical Research Project for Rare/Intractable Diseases" from Japan Agency for Medical Research and Development, AMED, Japan, 17ek0109115h0003, Principal Investigator, 2015-2018, (13) Practical Research Project for Rare/Intractable Diseases" from Japan Agency for Medical Research and Development, AMED, Japan, 18ek0109376h0001, Principal Investigator, 2018-2021, (14) Practical Research Project for Rare/Intractable Diseases" from Japan Agency for Medical Research and Development, AMED, Japan, 18ek0109308h0001, Principal Investigator, 2018-2021, (15) Health and Labour Sciences Research Grant on Intractable Diseases from the Ministry of Health, Labour, and Welfare, Japan, H29- Nanchitou(Nan)-Shitei-001, Co-investigator, 2017-2020, (16) Health and Labour Sciences Research Grant on Intractable Diseases from the Ministry of Health, Labour, and Welfare, Japan, H29-Nanchitou(Nan)-Ippan-043, Co- investigator, 2017-2020, (17) Health and Labour Sciences Research Grant on Intractable Diseases from the Ministry of Health, Labour, and Welfare, Japan, H29- Nanchitou(Nan)-Ippan-033, Co-investigator, 2017-2020, (18) Health and Labour Sciences Research Grant on Intractable Diseases from the Ministry of Health, Labour, and Welfare, Japan, H29-Nanchitou(Nan)-Ippan-009, Co- investigator, 2017-2020, (19) Health and Labour Sciences Research Grant on Intractable Diseases from the Ministry of Health, Labour, and Welfare, Japan, H28- Nanchitou(Nan)-Ippan-025, Principal Investigator, 2016- 2019, (20) Health and Labour Sciences Research Grant on Intractable Diseases from the Ministry of Health, Labour, and Welfare, Japan, H28-Nanchitou(Nan)-Ippan-018, Co-investigator, 2016-2019

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurology (T.F., Y.M., R.Y., K.I., A.S., J.-i.K.), Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Neurology (E.-J.L., Y.-M.L., K.-K.K.), Asan Medical Center, University of Ulsan, College of Medicine, Seoul, South Korea; Translational Neuroscience Center (J.-i.K.), Graduate School of Medicine, and School of Pharmacy at Fukuoka, International University of Health and Welfare, Okawa; and Department of Neurology (J.-i.K.), Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, Japan.
  1. Correspondence
    Dr. Kira kira{at}neuro.med.kyushu-u.ac.jp
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