Predicting Aggressive Multiple Sclerosis With Intrathecal IgM Synthesis Among Patients With a Clinically Isolated Syndrome
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Article Information
- Received February 25, 2021
- Accepted in final form June 14, 2021
- First Published July 22, 2021.
Author Disclosures
- Enric Monreal, MD,
- Susana Sainz de la Maza, MD (susanasmc85{at}hotmail.com),
- Lucienne Costa-Frossard, MD (lufrossard{at}yahoo.es),
- Paulette Walo-Delgado, MD (pauletteesperanz.walo{at}salud.madrid.org),
- Javier Zamora, PhD (javierza{at}gmail.com),
- José Ignacio Fernández-Velasco, MSc (jfvelasco{at}salud.madrid.org),
- Noelia Villarrubia, PhD (noelia.villarrubia{at}salud.madrid.org),
- Mercedes Espiño, PhD (mercedes.espino{at}salud.madrid.org),
- Daniel Lourido, MD (louridodaniel{at}hotmail.com),
- Paloma Lapuente, MD (paloma.lapuente{at}salud.madrid.org),
- Inmaculada Toboso, PhD (inma.toboso.delamo{at}gmail.com),
- José Carlos Álvarez-Cermeño, PhD (josecarlos.alvarez{at}salud.madrid.org),
- Jaime Masjuan, PhD (jaime.masjuan{at}salud.madrid.org) and
- Luisa María Villar, PhD (luisamaria.villar{at}salud.madrid.org)
- Enric Monreal, MD,
(1) Sanofi-Genzyme
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(1) Biogen, funding for travel and speak to conference (2) Roche, funding for travel to conference (3) Almirall, funding for travel to conference (4) Sanofi-Genzyme, funding for travel to conference (5) Novartis, funding for travel to conference (6) Merck, funding for travel to conference
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(1) Lymphocytes subsets ratio to predict autoimmunity in patients treated with Alemtuzumab.
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(1) Merck, promotional campaign
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- Susana Sainz de la Maza, MD (susanasmc85{at}hotmail.com),
(1) Almirall (Comercial entity) (2) Merck (Commercial entity) (3) Sanofi-Genzyme (Commercial entity)
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(1) Biogen. Commercial entity. Speaker honoraria. (2) Merck. Commercial entity. Speaker honoraria. (3) Roche. Commercial entity. Speaker honoraria. (4) Sanofi-Genzyme. Commercial entity. Speaker honoraria. (5) Teva. Commercial entity. Speaker honoraria.
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17 382 331.1. Method for monitoring and predicting the efficacy of treatment in a multiple sclerosis patient España. 20/06/2017. FIBio-HRC.
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- Lucienne Costa-Frossard, MD (lufrossard{at}yahoo.es),
received payment for giving conferences, or travel expenses or research grants from Merck-Serono, Biogen, Sanofi-Genzyme, Roche, Bayer and Novartis. The remaining authors declare no conflicts of interest.
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received payment for giving conferences, or travel expenses or research grants from Merck-Serono, Biogen, Sanofi-Genzyme, Roche, Bayer and Novartis. The remaining authors declare no conflicts of interest.
Editorial Board Member in American Journal of Psychiatry and Neuroscience
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received payment for giving conferences, or travel expenses or research grants from Merck-Serono, Biogen, Sanofi-Genzyme, Roche, Bayer and Novartis. The remaining authors declare no conflicts of interest.
received payment for giving conferences, or travel expenses or research grants from Merck-Serono, Biogen, Sanofi-Genzyme, Roche, Bayer and Novartis. The remaining authors declare no conflicts of interest.
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- Paulette Walo-Delgado, MD (pauletteesperanz.walo{at}salud.madrid.org),
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Patent No. 20382988.2 - 1118 Predictive biomarkers of autoimmunity in patients treated with alemtuzumab
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- Javier Zamora, PhD (javierza{at}gmail.com),
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- José Ignacio Fernández-Velasco, MSc (jfvelasco{at}salud.madrid.org),
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- Noelia Villarrubia, PhD (noelia.villarrubia{at}salud.madrid.org),
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(1)Fondo para la Investigación Sanitaria from the Instituto de Salud Carlos III, the Ministerio de Ciencia e Innovación (Spain) and Fondo Europeo de Desarrollo Regional (FEDER), grant number: RD16/0015/0001, 2019-2021 (2)Fondo para la Investigación Sanitaria from the Instituto de Salud Carlos III, the Ministerio de Ciencia e Innovación (Spain) and Fondo Europeo de Desarrollo Regional (FEDER), grant number: PI18/00572, 2017-2021
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- Mercedes Espiño, PhD (mercedes.espino{at}salud.madrid.org),
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- Daniel Lourido, MD (louridodaniel{at}hotmail.com),
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- Paloma Lapuente, MD (paloma.lapuente{at}salud.madrid.org),
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- Inmaculada Toboso, PhD (inma.toboso.delamo{at}gmail.com),
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- José Carlos Álvarez-Cermeño, PhD (josecarlos.alvarez{at}salud.madrid.org),
Genzyme, Araclon Biotech
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- Jaime Masjuan, PhD (jaime.masjuan{at}salud.madrid.org) and
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- Luisa María Villar, PhD (luisamaria.villar{at}salud.madrid.org)
Genzyme, Biogen, Merck, Novartis
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Biogen: Funding for travel or speaker honorariaMerck: Funding for travel or speaker honorariaNovartis: Funding for travel or speaker honorariaGenzyme: Funding for travel or speaker honorariaRoche: Funding for travel or speaker honoraria
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Biomarker for selecting good responders to IFN beta in multiple sclerosis
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I have received payment for consultancies fromBiogen Idec, Merck, Novartis, (Commercial entities)
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Genzyme; Merck; Biogen; Roche
Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (ISCIII). Grant N. PI18/00572 for the research in MS. Years 2019-2021
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- From the Department of Neurology (E.M., S.S.d.l.M., L.C.-F., J.C.Á.-C., J.M.), and Department of Immunology (P.W.-D., J.I.F.-V., N.V., M.E., P.L., I.T., L.M.V.), Hospital Universitario Ramón y Cajal, REEM, IRYCIS; Clinical Biostatistics Unit (J.Z.), Hospital Universitario Ramón y Cajal, IRYCIS, CIBERESP, Madrid, Spain; Institute of Metabolism and System Research (J.Z.), University of Birmingham, United Kingdom; and Department of Radiology (D.L.), Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
- Correspondence
Dr. Monreal enricmonreal{at}outlook.com
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