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September 2021; 8 (5) ArticleOpen Access

Predicting Aggressive Multiple Sclerosis With Intrathecal IgM Synthesis Among Patients With a Clinically Isolated Syndrome

Enric Monreal, Susana Sainz de la Maza, Lucienne Costa-Frossard, Paulette Walo-Delgado, Javier Zamora, José Ignacio Fernández-Velasco, Noelia Villarrubia, Mercedes Espiño, Daniel Lourido, Paloma Lapuente, Inmaculada Toboso, José Carlos Álvarez-Cermeño, Jaime Masjuan, Luisa María Villar
First published July 22, 2021, DOI: https://doi.org/10.1212/NXI.0000000000001047
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Figures

  • Figure 1
    Figure 1 Flowchart of Participants

    CIS = clinically isolated syndrome; Ig = immunoglobulin; MS = multiple sclerosis.

  • Figure 2
    Figure 2 Time to a Second Relapse With All Methods Assessing ITMS

    Kaplan-Meier survival curves and results from the log-rank test for the survival-free probability of a second relapse with (A) OCMB, (B) LS-OCMB, (C) Reibergram, and (D) IgM index. Ig = immunoglobulin; ITMS = intrathecal IgM synthesis; OCMB = IgM oligoclonal band; LS-OCMB = lipid-specific IgM oligoclonal band.

  • Figure 3
    Figure 3 Time to EDSS Scores of 4 and 6 and Conversion to Secondary Progressive Multiple Sclerosis With LS-OCMB and Reibergram

    Cumulative incidence and results from the log-rank test for (A, B) EDSS score 4, (C, D) EDSS score 6, and (E, F) development of SPMS with (A, C, E) LS-OCMB and (B, D, F) Reibergram. EDSS = Expanded Disability Status Scale; Ig = immunoglobulin; LS-OCMB = lipid-specific IgM oligoclonal band; SPMS = secondary progressive multiple sclerosis.

  • Figure 4
    Figure 4 Time to EDSS Scores of 4 and 6 and Conversion to Secondary Progressive Multiple Sclerosis With OCMB and IgM Index

    Cumulative incidence with the log-rank test results for (A, B) EDSS score 4, (C, D) EDSS score 6, and (E, F) development of SPMS with (A, C, E) OCMB and (B, D, F) IgM index. EDSS = Expanded Disability Status Scale; Ig = immunoglobulin; OCMB = IgM oligoclonal band.

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