Article Figures & Data
Figures
- Figure 1 Regional Analyses of GM Volume and CT Differences Between Groups
(A) Example of FIRST deep GM structure segmentation in subject space. Compared with HCs, patients with RRMS showed a significant reduction in the left and right thalami. (B) Neuromorphometrics atlas used for cortical GM volume analysis in which, compared with HCs, patients with RRMS showed a significant reduction in the left inferior frontal orbitofrontal gyrus GM volume after application of FDR multiple comparison correction. After Holm-Bonferroni multiple comparison corrections, no significant effects were observed. (C) Desikan-Killiany atlas used for regional CT analysis in which patients with RRMS showed a significant reduction in CT in bilateral temporal, parietal, and frontal areas compared with HCs after FDR multiple comparison correction. After Holm-Bonferroni multiple comparison correction, patients with RRMS showed a significant reduction in CT only in the right TTG and right STG compared with HCs. CT = cortical thickness; FDR = false discovery rate; FIRST = FMRIB's Integrated Registration and Segmentation Tool; GM = gray matter; HC = healthy control; RRMS = relapsing-remitting multiple sclerosis; TTG = transverse temporal gyrus.
- Figure 2 Associations Between Regression Standardized Predicted Values and Global Cognitive Status (ZG Scores) in the RRMS Group
(A) Stepwise regression model retaining STAI state anxiety scores (β = −0.412, t = −2.969), sNfL levels (β = −0.367, t = −2.632), and global CT values CT (β = 0.354; t = 2.546) as significant predictors of global cognitive status (ZG scores) in the RRMS group (adjusted R2 = 0.404; p < 0.001). (B) Stepwise regression model including regional radiologic variables, retaining STAI state anxiety scores (β = −0.529, t = −3.751), sNfL levels (β = −0.419, t = −3.018) and right TTG thickness (β = 0.409; t = 2.853) as significant predictors of global cognitive status (ZG scores) in the RRMS group (adjusted R2 = 0.429; p < 0.001). CT = cortical thickness; RRMS = relapsing-remitting multiple sclerosis; sNfL = serum neurofilament light chain; TTG = transverse temporal gyrus; ZG = global cognitive Z score.
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