Article Figures & Data
Figures
- Figure 1 Association Plots for Anti-NMDAR Encephalitis
(A) Quantile-quantile plot of association analysis for 8,073,349 variants. The plot shows deviation from the null distribution in the upper tail, which corresponds to variants with the strongest evidence for association. (B) Manhattan plot of the association results. The plot shows −log10 marker-wise p values against their genomic base pair position. The red line indicates the genome-wide significance threshold of 5 × 10−8. (C) LocusZoom plot for the association between anti-NMDA receptor encephalitis and variants on chromosome 11 in the genomic region from 46.6 to 48.2 Mb. A circle represents a genotyped and a plus symbol an imputed variant. The r2 metric displays the pairwise LD between the leading and the respective variant. Gene positions are present in the bottom part. (D) LocusZoom plot for associations on chromosome 15 in the genomic region from 100.9 to 101.1 Mb.
- Figure 2 Colocalization Results for Brain Tissues
Gene- and SNP-wise results of the colocalization analysis for brain tissues represented in Genotype-Tissue Expression types. Only genes with a PP4 > 0.7 and variants with a p value < 10−5 are shown. ACP2 = acid phosphatase 2, lysosomal; GWAS = genome-wide association study; MADD = mitogen-activated protein kinase activating death domain; NR1H3 = nuclear receptor subfamily 1 group H member 3.
- Figure 3 Colocalization Results for Immune Cells
Gene- and SNP-wise results of the colocalization for immune cells represented in the BLUEPRINT data set. Only genes with a PP4 > 0.7 and variants with a p value < 10−5 are shown. ACP2 = acid phosphatase 2, lysosomal; C11orf49 = chromosome 11 open reading frame 49; DDB2 = damage-specific DNA binding protein 2; GWAS = genome-wide association study; NR1H3 = nuclear receptor subfamily 1 group H member 3.
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