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January 2022; 9 (1) ArticleOpen Access

Impact of Dietary Intervention on Serum Neurofilament Light Chain in Multiple Sclerosis

Markus Bock, Falk Steffen, Frauke Zipp, Stefan Bittner
First published November 11, 2021, DOI: https://doi.org/10.1212/NXI.0000000000001102
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  • Figure 1
    Figure 1 Intra-Group Comparison – Adapted Ketogenic Diet Lowers the Serum Concentration of Neurofilament Light Chain II

    Alterations of serum neurofilament light chain (sNfL) levels induced by caloric restriction and adapted ketogenic diet. Data represent mean ± standard error of the mean and were measured at baseline and retested at 6 months for all groups. p values indicate Wilcoxon matched-pairs signed rank test analysis, *p < 0.05.

  • Figure 2
    Figure 2 Comparison of sNfL Levels in Patients With MS on Adapted Ketogenic Diet With Common Diet

    After 6 months of adapted ketogenic diet, the serum neurofilament light chain (sNfL) concentration declined significantly compared to the common diet group. Data were measured at baseline and retested at 6 months. Data represent mean ± standard error of the mean. **p < 0.01, analysis of covariance (ANCOVA) adjusted for relapse rate, BMI and baseline dependencies.

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