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January 2022; 9 (1) ArticleOpen Access

Decrease in Serum Anti-MAG Autoantibodies Is Associated With Therapy Response in Patients With Anti-MAG Neuropathy

Retrospective Study

View ORCID ProfilePascal Hänggi, View ORCID ProfileButrint Aliu, View ORCID ProfileKea Martin, Ruben Herrendorff, Andreas Johann Steck
First published November 10, 2021, DOI: https://doi.org/10.1212/NXI.0000000000001109
Pascal Hänggi
From the Polyneuron Pharmaceuticals AG (P.H.,K.M.,R.H.), Basel; Molecular Pharmacy (P.H.,B.A.,R.H.), Pharmacenter, University of Basel; and Clinic of Neurology (A.J.S.), Department of Medicine, University Hospital Basel, University of Basel, Switzerland.
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  • ORCID record for Pascal Hänggi
Butrint Aliu
From the Polyneuron Pharmaceuticals AG (P.H.,K.M.,R.H.), Basel; Molecular Pharmacy (P.H.,B.A.,R.H.), Pharmacenter, University of Basel; and Clinic of Neurology (A.J.S.), Department of Medicine, University Hospital Basel, University of Basel, Switzerland.
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  • For correspondence: b.aliu@unibas.ch
Kea Martin
From the Polyneuron Pharmaceuticals AG (P.H.,K.M.,R.H.), Basel; Molecular Pharmacy (P.H.,B.A.,R.H.), Pharmacenter, University of Basel; and Clinic of Neurology (A.J.S.), Department of Medicine, University Hospital Basel, University of Basel, Switzerland.
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  • For correspondence: k.martin@polyneuron.com
Ruben Herrendorff
From the Polyneuron Pharmaceuticals AG (P.H.,K.M.,R.H.), Basel; Molecular Pharmacy (P.H.,B.A.,R.H.), Pharmacenter, University of Basel; and Clinic of Neurology (A.J.S.), Department of Medicine, University Hospital Basel, University of Basel, Switzerland.
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Andreas Johann Steck
From the Polyneuron Pharmaceuticals AG (P.H.,K.M.,R.H.), Basel; Molecular Pharmacy (P.H.,B.A.,R.H.), Pharmacenter, University of Basel; and Clinic of Neurology (A.J.S.), Department of Medicine, University Hospital Basel, University of Basel, Switzerland.
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  • For correspondence: andreas.steck@unibas.ch
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Citation
Decrease in Serum Anti-MAG Autoantibodies Is Associated With Therapy Response in Patients With Anti-MAG Neuropathy
Retrospective Study
Pascal Hänggi, Butrint Aliu, Kea Martin, Ruben Herrendorff, Andreas Johann Steck
Neurol Neuroimmunol Neuroinflamm Jan 2022, 9 (1) e1109; DOI: 10.1212/NXI.0000000000001109

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    Figure 1 Overview of the Systematic Literature Search in Medline Epub

    An All published work has been included until January 29, 2020, independent of the type of intervention or class of evidence given the limited number of Class I evidence studies. Data of 50 publications were included and analyzed.

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    Figure 2 Relative Change in Serum Anti-MAG IgM Titers or Levels and Response to Immunotherapies in Patients With Anti-MAG Neuropathy

    An overview of the studies that assessed the relative change in anti-MAG IgM autoantibodies (pretreatment and posttreatment) and clinical response to immunotherapies. (A) Relative change in anti-MAG IgM titers in the responder (a) and the nonresponder group (b); (B) Relative change in paraprotein levels in the responder and the nonresponder group; and (C) Relative change in total IgM levels in the responder and the nonresponder group. Data are indicated as mean values and the circle size represents comparative size of the study (number of participants). MAG = myelin‐associated glycoprotein.

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    Figure 3 Comparison of the Relative Change in Serum anti-MAG IgM Titers or Levels Between Responder, Nonresponder, and Acute Deteriorating Groups

    Comparison of clinical improvement and relative change in serum anti-MAG IgM titers, paraprotein levels, and total IgM levels in the (A) responder group, (B) nonresponder group, (C) and the acute deteriorating group. Data are shown as median and 95% confidence intervals. MAG = myelin‐associated glycoprotein.

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    Figure 4 Analysis of the Clinical Study Patient Population

    (A) Mean age at onset of the neuropathy and (B) the mean age at the start of the clinical study was significantly lower in the responder group (n = 208 participants) compared with the nonresponder group (n = 191 participants); (C) The difference in disease duration until the patients participated in the clinical study was not significant. Data are shown as median and 95% confidence intervals, an independent t-test and Tukey Kramer test were performed (p < 0.05).

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