Stress Signal ULBP4, an NKG2D Ligand, Is Upregulated in Multiple Sclerosis and Shapes CD8+ T-Cell Behaviors
Citation Manager Formats
Make Comment
See Comments

Article Information
- Received August 17, 2021
- Accepted in final form October 19, 2021
- First Published December 6, 2021.
Author Disclosures
- Ana Carmena Moratalla, MSc (anacarmena3{at}gmail.com),
- Yves Carpentier Solorio, BSc (yves.carpentier.solorio{at}umontreal.ca),
- Florent Lemaitre, MSc (grdflo.lemaitre{at}gmail.com),
- Negar Farzam-kia, BSc (negarf.16{at}gmail.com),
- Annie Levert, DEC (annie.levert2{at}hotmail.com),
- Stephanie E.J. Zandee, PhD (stephaniezandee{at}gmail.com),
- Boaz Lahav, BSc (boaz.lahav.chum{at}ssss.gouv.qc.ca),
- Jean Victor Guimond, MD (jeanvictorguimondjvg{at}gmail.com),
- Elie Haddad, MD, PhD (elie.haddad{at}umontreal.ca),
- Marc Girard, MD (m_girard{at}videotron.ca),
- Pierre Duquette, MD (pierre.duquette.1{at}umontreal.ca),
- Catherine Larochelle, MD, PhD (catherine.larochelle.med{at}ssss.gouv.qc.ca),
- Alexandre Prat, MD, PhD (a.prat{at}umontreal.ca) and
- Nathalie Arbour, PhD
- Ana Carmena Moratalla, MSc (anacarmena3{at}gmail.com),
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Yves Carpentier Solorio, BSc (yves.carpentier.solorio{at}umontreal.ca),
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Florent Lemaitre, MSc (grdflo.lemaitre{at}gmail.com),
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Negar Farzam-kia, BSc (negarf.16{at}gmail.com),
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Annie Levert, DEC (annie.levert2{at}hotmail.com),
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Stephanie E.J. Zandee, PhD (stephaniezandee{at}gmail.com),
None
NONE
Funding organization(s): Canadian Institutes of Health Research
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
None
NONE
NONE
NONE
NONE
NONE
NONE
- Boaz Lahav, BSc (boaz.lahav.chum{at}ssss.gouv.qc.ca),
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Jean Victor Guimond, MD (jeanvictorguimondjvg{at}gmail.com),
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Elie Haddad, MD, PhD (elie.haddad{at}umontreal.ca),
Enzyvant Jasper Therapeutics Rocket Pharma
NONE
NONE
NONE
Invention of specific promoters
NONE
NONE
NONE
NONE
NONE
NONE
NONE
CIHR
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Marc Girard, MD (m_girard{at}videotron.ca),
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Pierre Duquette, MD (pierre.duquette.1{at}umontreal.ca),
Member of advisory boards for Biogen-Idec, EMD Serono, Novartis, TEVANeuroscience, Genzyme.
NONE
NONE
NONE
Shared patent for a cellular adhesion molecule.
NONE
NONE
NONE
NONE
Organisation of CME activities with Biogen-Idec, EMD Serono, Novartis, TEVANeuroscience, Genzyme.
NONE
Investigator-initiated studies funded by Biogen-Idec, by Novartis,EMD Serono, and by Genzyme.
CIHR grant (co-investigator). MS Society of Canada (co-investigator).
MS Society of Canada.
NONE
NONE
NONE
NONE
NONE
NONE
NONE
- Catherine Larochelle, MD, PhD (catherine.larochelle.med{at}ssss.gouv.qc.ca),
Sanofi-Genzyme, Actelion, Novartis, Biogen, EMD-Serono
NONE
Sanofi-Genzyme, Novartis, Biogen, EMD-Serono
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
Grant for Multiple Sclerosis Innovation from Merck-EMD-Serono
CIHR, FRQ-S
NONE
Multiple Sclerosis Society of Canada
NONE
NONE
NONE
NONE
NONE
NONE
- Alexandre Prat, MD, PhD (a.prat{at}umontreal.ca) and
Biogen, EMD Serono, Teva, Celgene, Sanofi, Roche
NONE
NONE
(1) Multiple Sclerosis Journal, associate editor; (2) Cellular Immunology, associate editor
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
1-CIHR 2-MSSC 3-PMSA
NONE
NONE
NONE
NONE
NONE
NONE
NONE
Expert Opinion to the Federal Court of Canada
- Nathalie Arbour, PhD
NONE
NONE
NONE
Editoral Board for Multiple Sclerosis Journal NO compensation
NONE
NONE
NONE
NONE
NONE
NONE
NONE
NONE
Canadian Institutes of Health Research- 2014-2019 and 2020- 2025 Natural Sciences and Engineering Research Council-2019-2024
Research Chair Neurosurgery-Université de Montreal- 2019- 2024
Multiple Sclerosis Society of Canada 2017-2020
NONE
NONE
NONE
NONE
NONE
NONE
- From the Department of Neurosciences (A.C.M., Y.C.S., F.L., N.F-k., A.L., S.E.J.Z., M.G., P.D., C.L., A.P., N.A.), Université de Montréal and Centre de Recherche du CHUM (CRCHUM) Montreal; MS-CHUM Clinic (B.L., M.G., P.D., C.L., A.P.); CLSC des Faubourgs (J.V.G.), CIUSSS du Centre-Sud-de-l’Ile-de-Montréal; and Department of Microbiology, Infectious Diseases, and Immunology and Department of Pediatrics (E.H.), Université de Montréal, Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine (CHU Sainte-Justine), Montreal, Quebec, Canada.
- Correspondence
Dr. Arbour nathalie.arbour{at}umontreal.ca
Article usage
Cited By...
Letters: Rapid online correspondence
REQUIREMENTS
If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Dr. Daniel Friedman and Dr. Sharon Chiang
► Watch
Related Articles
- No related articles found.