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March 2022; 9 (2) ArticleOpen Access

Optic Nerve Lesion Length at the Acute Phase of Optic Neuritis Is Predictive of Retinal Neuronal Loss

Mickael Denis, Jean-Philippe Woillez, View ORCID ProfileVasily M. Smirnov, View ORCID ProfileElodie Drumez, Julien Lannoy, Julie Boucher, Mickael Zedet, Jean-Pierre Pruvo, View ORCID ProfileJulien Labreuche, Helene Zephir, Xavier Leclerc, Olivier Outteryck
First published January 28, 2022, DOI: https://doi.org/10.1212/NXI.0000000000001135
Mickael Denis
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • For correspondence: mickael-denis@hotmail.fr
Jean-Philippe Woillez
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • For correspondence: docteur.jp.woillez@wanadoo.fr
Vasily M. Smirnov
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • ORCID record for Vasily M. Smirnov
  • For correspondence: vasily.smirnov@chu-lille.fr
Elodie Drumez
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • ORCID record for Elodie Drumez
  • For correspondence: edrumezchr@gmail.com
Julien Lannoy
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • For correspondence: julien.lannoy@chru-lille.fr
Julie Boucher
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • For correspondence: julie.boucher@chru-lille.fr
Mickael Zedet
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • For correspondence: mickael.zedet@hotmail.fr
Jean-Pierre Pruvo
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • For correspondence: jppruvo@gmail.com
Julien Labreuche
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • ORCID record for Julien Labreuche
  • For correspondence: julien.labreuche.chru@gmail.com
Helene Zephir
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • For correspondence: helene.zephir@chru-lille.fr
Xavier Leclerc
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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  • For correspondence: xavier.leclerc@chru-lille.fr
Olivier Outteryck
From the Univ. Lille (M.D., J.-P.P., X.L., O.O.), Department of Neuroradiology, INSERM, CHU Lille, U1172—Lille Neurosciences Institute; Univ. Lille (J.-P.W., V.M.S.), Department of Visual Explorations and Neuro-Ophthalmology, Hôpital Roger Salengro, CHU Lille; Univ. Lille (E.D., Julien Labreuche), CHU Lille, EA 2694—Santé publique: épidémiologie et qualité des soins, Department of Biostatistics; and Univ. Lille (Julien Lannoy, J.B., M.Z., H.Z.), Department of Neurology, INSERM, CHU Lille, U1172–Lille Neurosciences Institute, France.
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Citation
Optic Nerve Lesion Length at the Acute Phase of Optic Neuritis Is Predictive of Retinal Neuronal Loss
Mickael Denis, Jean-Philippe Woillez, Vasily M. Smirnov, Elodie Drumez, Julien Lannoy, Julie Boucher, Mickael Zedet, Jean-Pierre Pruvo, Julien Labreuche, Helene Zephir, Xavier Leclerc, Olivier Outteryck
Neurol Neuroimmunol Neuroinflamm Mar 2022, 9 (2) e1135; DOI: 10.1212/NXI.0000000000001135

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    Figure 1 Optic Nerve MRI Findings in a Patient With CIS

    (A) Patient with CIS presenting a left clinical episode of acute optic neuritis. A symptomatic optic nerve lesion (arrowhead) and a right asymptomatic optic nerve lesion (white arrow) were detected on 3D-Double-Inversion Recovery MR sequence. MRI reconstruction of left and right optic nerves showing symptomatic (arrowheads) and asymptomatic (white arrows) lesions in sagittal optic nerve planes (B) and coronal planes (C). CIS = clinically isolated syndrome

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    Figure 2 Flowchart of IRMANO Cohort and the Corresponding Eyes' Subgroups According to the Occurrence of an Acute ON, ON History, and Optic Nerve MRI Data

    The authors recruited 51 patients presenting an acute episode of ON. One patient with acute ON did not present any optic nerve lesion on MRI. One patient with RRMS presented a bilateral acute ON. All eyes with a history of ON presented an optic nerve lesion. Some patients with CIS and RRMS presented an asymptomatic optic nerve lesion on the fellow eye. CIS = clinically isolated syndrome; DIR = double-inversion recovery; NMOSD = neuromyelitis optica spectrum disorders; ON = optic neuritis; RRMS = relapsing-remitting multiple sclerosis.

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    Figure 3 Optic Nerve MRI of a CIS Patient With Detection of a New Asymptomatic Optic Nerve Lesion During the Follow-up

    Optic nerve MRI of a patient with CIS presenting a left acute optic neuritis. At inclusion, no lesion was detected on the right optic nerve. At M12, a new right asymptomatic retrobulbar optic nerve DIR hypersignal was detected (white arrows). CIS = clinically isolated syndrome.

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