Article Figures & Data
Figures
- Figure 1 PET Signal in the Pseudoreference Region and Normalized SUVR Values in Target ROIs
Statistically obtained pseudoreference region used to normalize PET images to obtain SUVR values (A). SUV values, adjusted for age, sex, and genotype, within this pseudoreference region in HCs, ECs, and PWH (B), boxplots of [11C]-PBR28 SUVR values, adjusted for age, sex, and genotype, extracted from anatomically defined ROIs (thalamus [C.a], parietal operculum cortex [C.b], and white matter [C.c]) in HCs, ECs, and PWH (C.a–c). *p < 0.05 (Dunnett test). EC = elite controller; HC = healthy control; PWH = people with HIV; ROI = region of interest; SUVR = standard uptake value ratio.
- Figure 2 Contrast-Defined ROI Analyses
Whole-brain voxelwise ANOVA contrast, identifying regions with significantly different PET signal between groups (A). Voxels marked with cyan and red-yellow colors represent regions identified as statistically significant using a cluster-forming threshold of 2.3 and 3.1, respectively. Regions with significant difference (A) were intersected with labels from the Harvard-Oxford Structural Atlas, to identify contrast-defined ROIs. Mean SUVRs extracted from 3 of these regions (displayed in green): prefrontal cortex (B.a), cerebellum (B.b), and insula (B.c) ROIs (B.a–c). *p < 0.05 (Dunnett test). ANOVA = analysis of variance; EC = elite controller; HC = healthy control; PWH = people with HIV; ROI = region of interest; SUVR = standard uptake value ratio.
- Figure 3 Voxelwise Group Comparisons of [11C]-PBR28 PET Signal
Results of voxelwise group comparison analysis between ECs and PWH (A) and between ECs and HCs (B). Voxels marked with cyan color and red-yellow colors represent regions identified as statistically significant using a cluster-forming threshold of 2.3 and 3.1, respectively. EC = elite controller; HC = healthy control; PWH = people with HIV; SUVR = standard uptake value ratio.
- Figure 4 Relationship Between [11C]-PBR28 PET and MRI Measurements in Thalamus PET
SUVR against T1 relaxation time (A) and T2 relaxation time (B) for each subject's thalamus. The color represents the point density. R is the adjusted ρ value from the Spearman correlation test. Plots in red boxes belong to HABs. HAB = high-affinity binder; SUVR = standard uptake value ratio.
- Figure 5 Relationship Between [11C]-PBR28 PET and MRI Measurements in the White Matter
PET SUVR against T1 relaxation time (A) and T2 relaxation time (B) for each subject's white matter. The color represents the points density. R is the adjusted rho value from the Spearman correlation test. Plots in red boxes belong to HABs. HAB = high-affinity binder; SUVR = standard uptake value ratio.
- Figure 6 Putative Mechanism of [11C]-PBR28 Uptake, T1, and T2 Relationships in the Tissue
TSPO = translocator protein 18 kDa.
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