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May 2022; 9 (3) Research ArticleOpen Access

Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis

View ORCID ProfileLilian Aly, Christina Noll, Rebecca Wicklein, Elisabeth Wolf, Eva Feodora Romahn, Josphine Wauschkuhn, Sami Hosari, Christian Mardin, View ORCID ProfileAchim Berthele, View ORCID ProfileBernhard Hemmer, View ORCID ProfileThomas Korn, View ORCID ProfileBenjamin Knier
First published March 17, 2022, DOI: https://doi.org/10.1212/NXI.0000000000001159
Lilian Aly
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • ORCID record for Lilian Aly
  • For correspondence: lilian.aly@tum.de
Christina Noll
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • For correspondence: christina.noll@tum.de
Rebecca Wicklein
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • For correspondence: rebecca.wicklein@tum.de
Elisabeth Wolf
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • For correspondence: e.wolf.1997@web.de
Eva Feodora Romahn
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • For correspondence: feodora.romahn@tum.de
Josphine Wauschkuhn
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • For correspondence: josephine.wauschkuhn@gmail.com
Sami Hosari
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • For correspondence: sami.hosari@uk-erlangen.de
Christian Mardin
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • For correspondence: christian.mardin@uk-erlangen.de
Achim Berthele
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • ORCID record for Achim Berthele
  • For correspondence: achim.berthele@tum.de
Bernhard Hemmer
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • ORCID record for Bernhard Hemmer
  • For correspondence: hemmer@tum.de
Thomas Korn
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • ORCID record for Thomas Korn
  • For correspondence: thomas.korn@tum.de
Benjamin Knier
From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
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  • ORCID record for Benjamin Knier
Full PDF
Citation
Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis
Lilian Aly, Christina Noll, Rebecca Wicklein, Elisabeth Wolf, Eva Feodora Romahn, Josphine Wauschkuhn, Sami Hosari, Christian Mardin, Achim Berthele, Bernhard Hemmer, Thomas Korn, Benjamin Knier
Neurol Neuroimmunol Neuroinflamm May 2022, 9 (3) e1159; DOI: 10.1212/NXI.0000000000001159

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Article Information

vol. 9 no. 3 e1159
DOI: 
https://doi.org/10.1212/NXI.0000000000001159
PubMed: 
35301260

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Online ISSN: 
2332-7812
History: 
  • Received October 23, 2021
  • Accepted in final form January 3, 2022
  • First Published March 17, 2022.

Copyright & Usage: 
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Lilian Aly, MD (lilian.aly{at}tum.de),
    2. Christina Noll (christina.noll{at}tum.de),
    3. Rebecca Wicklein, MD (rebecca.wicklein{at}tum.de),
    4. Elisabeth Wolf (e.wolf.1997{at}web.de),
    5. Eva Feodora Romahn (feodora.romahn{at}tum.de),
    6. Josphine Wauschkuhn (josephine.wauschkuhn{at}gmail.com),
    7. Sami Hosari, MD (sami.hosari{at}uk-erlangen.de),
    8. Christian Mardin, MD (christian.mardin{at}uk-erlangen.de),
    9. Achim Berthele, MD (achim.berthele{at}tum.de),
    10. Bernhard Hemmer, MD (hemmer{at}tum.de),
    11. Thomas Korn, MD (thomas.korn{at}tum.de) and
    12. Benjamin Knier, MD
  1. Lilian Aly, MD (lilian.aly{at}tum.de),
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. Novartis Funding for travel to the MS Research Day Berlin, 2020

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Christina Noll (christina.noll{at}tum.de),
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Gemeinnützige Hertie Foundation (medMS program)

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Rebecca Wicklein, MD (rebecca.wicklein{at}tum.de),
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. Travel Grant ECTRIMS 2021 for Poster presentation

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. Research fellowship of Klinikum rechts der Isar, Technische Universität Munich

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Elisabeth Wolf (e.wolf.1997{at}web.de),
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Eva Feodora Romahn (feodora.romahn{at}tum.de),
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Josphine Wauschkuhn (josephine.wauschkuhn{at}gmail.com),
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Sami Hosari, MD (sami.hosari{at}uk-erlangen.de),
  14. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  15. Christian Mardin, MD (christian.mardin{at}uk-erlangen.de),
  16. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. Heidelberg Engineering, Heidelberg, Germany

    Editorial Boards:
    1. Klinische Monatsblätter Augenheilkunde 2020-2022

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  17. Achim Berthele, MD (achim.berthele{at}tum.de),
  18. Scientific Advisory Boards:
    1. (1) Alexion Pharma (2) Biogen (3) Celgene (4) Roche Pharma (5) Hexal/Novartis

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) Alexion Pharma, funding for travel and speaker honoraria (2) Bayer Healthcare, speaker honoraria (3) Biogen, speaker honoraria (4) Roche Pharma, funding for travel and speaker honoraria.

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  19. Bernhard Hemmer, MD (hemmer{at}tum.de),
  20. Scientific Advisory Boards:
    1. Advisory Boards for Novartis, he has served as DSMB member for AllergyCare, TG Therapeutics and Polpharma Biologics

    Gifts:
    1. Me or my institution have received speaker honoraria from Desitin

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Editorial board member of Experimental Neurology and Multiple sclerosis Journal

    Patents:
    1. I hold part of two patents; one for the detection of antibodies and T cells against KIR4.1 in a subpopulati on of MS patients and one for genetic determinants of neutralizing antibodies to interferon beta

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Regeneron - not related, Research grants from the German research foundation, the Bundesministerium für Bildung und Forschung and the European Community

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  21. Thomas Korn, MD (thomas.korn{at}tum.de) and
  22. Scientific Advisory Boards:
    1. (1) Sanofi Genzyme (2) Novartis (3) Roche (4) Janssen

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) Novartis (2) Alexion

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. (1) Deutsche Forschungsgemeinschaft (DFG): KO2964/2-1, KO2964/3-1, KO2964/4-1, KO2964/5-1, SFB1054- B06, TRR128-A07, TRR128-A12, TRR274-A01, Synergy EXC2145. (2) European Research Council (ERC): CoG647215.

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. (1) Gemeinnützige Hertie-Stiftung (Hertie Foundation).

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  23. Benjamin Knier, MD
  24. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) Bayer, Travel Compensation (2) Merck Serono, Travel Compensation (3) ECTRIMS (non-profit), travel grant (4) Neurowind e.V. (non-profit), travel grant (5) Novartis, Travel Compensation

    Editorial Boards:
    1. (1) Frontiers in Neurology, Review Editor, 2020 (2) Frontiers in Immunology, Review Editor, 2021

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. (1) Novartis, research grant (2) Novartis, research award "Oppenheim research fund"

    Research Support, Government Entities:
    1. (1) Kompetenznetz Multiple Sklerose (non-profit) of the Bundesministerium für Bildung und Forschung, seed research grant, 2014

    Research Support, Academic Entities:
    1. (1) Kommission für Klinische Foschung (KKF), intramural research grant from the Technical University of Munich

    Research Support, Foundations and Societies:
    1. (1) Else Kröner Fresenius-Stiftung, Else Kröner Exzellenzstipendium 2019

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Department of Neurology (L.A., C.N., R.W., E.W., E.F.R., J.W., A.B., B.H., T.K., B.K.), Klinikum rechts der Isar, Institute for Experimental Neuroimmunology (L.A., T.K., B.K.), Technical University of Munich; Department of Ophthalmology (S.H., C.M.), University Hospital of Erlangen-Nuremberg; and Munich Cluster for Systems Neurology (SyNergy) (B.H., T.K.), Germany.
  1. Correspondence
    Dr. Knier benjamin.knier{at}tum.de
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