July 2022; 9 (4) Research ArticleOpen Access
Retinal Hyperreflecting Foci Associate With Cortical Pathology in Multiple Sclerosis
Marta Pengo, Silvia Miante, Silvia Franciotta, Marta Ponzano, Tommaso Torresin, View ORCID ProfileFrancesca Bovis, Francesca Rinaldi, Paola Perini, Martina Saiani, Monica Margoni, Alessandra Bertoldo, Maria Pia Sormani, Elisabetta Pilotto, Edoardo Midena, Paolo Gallo, Marco Puthenparampil
First published May 23, 2022, DOI: https://doi.org/10.1212/NXI.0000000000001180
Marta Pengo
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Silvia Miante
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Silvia Franciotta
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Marta Ponzano
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Tommaso Torresin
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Francesca Bovis
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Francesca Rinaldi
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Paola Perini
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Martina Saiani
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Monica Margoni
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Alessandra Bertoldo
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Maria Pia Sormani
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Elisabetta Pilotto
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Edoardo Midena
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Paolo Gallo
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Marco Puthenparampil
From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
Retinal Hyperreflecting Foci Associate With Cortical Pathology in Multiple Sclerosis
Marta Pengo, Silvia Miante, Silvia Franciotta, Marta Ponzano, Tommaso Torresin, Francesca Bovis, Francesca Rinaldi, Paola Perini, Martina Saiani, Monica Margoni, Alessandra Bertoldo, Maria Pia Sormani, Elisabetta Pilotto, Edoardo Midena, Paolo Gallo, Marco Puthenparampil
Neurol Neuroimmunol Neuroinflamm Jul 2022, 9 (4) e1180; DOI: 10.1212/NXI.0000000000001180
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Article Information
vol. 9 no. 4 e1180
PubMed:
Online ISSN:
History:
- Received August 17, 2021
- Accepted in final form March 8, 2022
- First Published May 23, 2022.
Copyright & Usage:
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
Author Disclosures
- Marta Pengo, MD (marta.pengo4{at}gmail.com),
- Silvia Miante, MD (silvia.miante{at}gmail.com),
- Silvia Franciotta, MD (silvia.franciotta{at}gmail.com),
- Marta Ponzano, MSc (ponzano.marta{at}gmail.com),
- Tommaso Torresin, MD (tommaso.torresin{at}unipd.it),
- Francesca Bovis, PhD (francesca.bovis{at}gmail.com),
- Francesca Rinaldi, MD (dr.francesca.rinaldi{at}gmail.com),
- Paola Perini, MD (dr.paola.perini{at}gmail.com),
- Martina Saiani, MD (martina.saiani{at}tiscali.it),
- Monica Margoni, MD (monica.margoni{at}phd.unipd.it),
- Alessandra Bertoldo, PhD (alessandra.bertoldo{at}unipd.it),
- Maria Pia Sormani, PhD (mariapia.sormani{at}unige.it),
- Elisabetta Pilotto, MD, PhD (elisabetta.pilotto{at}unipd.it),
- Edoardo Midena, MD, PhD (edoardo.midena{at}unipd.it),
- Paolo Gallo, MD, PhD* (paolo.gallo{at}unipd.it) and
- Marco Puthenparampil, MD, PhD*
- Marta Pengo, MD (marta.pengo4{at}gmail.com),
- Silvia Miante, MD (silvia.miante{at}gmail.com),
- Silvia Franciotta, MD (silvia.franciotta{at}gmail.com),
- Marta Ponzano, MSc (ponzano.marta{at}gmail.com),
- Tommaso Torresin, MD (tommaso.torresin{at}unipd.it),
- Francesca Bovis, PhD (francesca.bovis{at}gmail.com),
- Francesca Rinaldi, MD (dr.francesca.rinaldi{at}gmail.com),
- Paola Perini, MD (dr.paola.perini{at}gmail.com),
- Martina Saiani, MD (martina.saiani{at}tiscali.it),
- Monica Margoni, MD (monica.margoni{at}phd.unipd.it),
- Alessandra Bertoldo, PhD (alessandra.bertoldo{at}unipd.it),
- Maria Pia Sormani, PhD (mariapia.sormani{at}unige.it),
- Elisabetta Pilotto, MD, PhD (elisabetta.pilotto{at}unipd.it),
- Edoardo Midena, MD, PhD (edoardo.midena{at}unipd.it),
- Paolo Gallo, MD, PhD* (paolo.gallo{at}unipd.it) and
- Marco Puthenparampil, MD, PhD*
- From the Multiple Sclerosis Centre (M. Pengo, S.M., S.F., M.S., M.M., P.G., M. Puthenparampil), Neurology Clinic, Department of Neuroscience, Università degli Studi di Padova; Department of Health Sciences (M. Ponzano, F.B., M.P.S.), Section of Biostatistics, University of Genova; Ophthalmology Clinic (T.T., E.P., E.M.), Department of Neuroscience, Università degli Studi di Padova, Italy; Fellow of the European Board of Ophthalmology (T.T., E.P., E.M.), London, United Kingdom; Multiple Sclerosis Centre (F.R., P.P.), Neurology Clinic, Azienda Ospedaliera di Padova; and Department of Information Engineering (DEI) (A.B.), University of Padova, Italy.
- Correspondence
Dr. Puthenparampil marco.puthenparampil{at}unipd.it
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