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September 2022; 9 (5) Research ArticleOpen Access

Long-term Effectiveness of IVIg Maintenance Therapy in 36 Patients With GAD Antibody–Positive Stiff-Person Syndrome

Jessica Yi, Marinos C. Dalakas
First published July 7, 2022, DOI: https://doi.org/10.1212/NXI.0000000000200011
Jessica Yi
From the Department of Neurology (J.Y., M.C.D.), Thomas Jefferson University, Philadelphia, PA; and National and Kapodistrian University of Athens (M.C.D.).
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Marinos C. Dalakas
From the Department of Neurology (J.Y., M.C.D.), Thomas Jefferson University, Philadelphia, PA; and National and Kapodistrian University of Athens (M.C.D.).
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Long-term Effectiveness of IVIg Maintenance Therapy in 36 Patients With GAD Antibody–Positive Stiff-Person Syndrome
Jessica Yi, Marinos C. Dalakas
Neurol Neuroimmunol Neuroinflamm Sep 2022, 9 (5) e200011; DOI: 10.1212/NXI.0000000000200011

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    Figure 1 Median Duration and Range of IVIg Treatment in 36 Patients With Stiff-Person Syndrome Categorized as IVIg Responders or Nonresponders

    IVIg responders were subcategorized based on their response to long-term treatment—continued benefit over time, decreasing benefit over time, demonstration of a conditioning effect, not assessed with a dependency trial, or unable to assess due to premature discontinuation of therapy.

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    Figure 2 Relative Proportion of Patients With Stiff-Person Syndrome Who Responded to IVIg Therapy in Each Subcategory of Responders With the Median Duration and Range of Treatment for Each Category

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