November 2022; 9 (6) Research ArticleOpen Access
CLMP Promotes Leukocyte Migration Across Brain Barriers in Multiple Sclerosis
Antoine Philippe Fournier, Stephanie Zandee, Marc Charabati, Evelyn Peelen, Olivier Tastet, Jorge Ivan Alvarez, Hania Kebir, Lyne Bourbonnière, Sandra Larouche, Boaz Lahav, Wendy Klement, Fiona Tea, Alain Bouthillier, Robert Moumdjian, Romain Cayrol, Pierre Duquette, Marc Girard, Catherine Larochelle, Nathalie Arbour, Alexandre Prat
First published September 9, 2022, DOI: https://doi.org/10.1212/NXI.0000000000200022
Antoine Philippe Fournier
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
PhDStephanie Zandee
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
PhDMarc Charabati
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MScEvelyn Peelen
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
PhDOlivier Tastet
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MScJorge Ivan Alvarez
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
PhDHania Kebir
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
PhDLyne Bourbonnière
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MScSandra Larouche
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
Boaz Lahav
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
BscWendy Klement
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MScFiona Tea
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
PhDAlain Bouthillier
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MDRobert Moumdjian
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MDRomain Cayrol
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MD, PhDPierre Duquette
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MDMarc Girard
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MDCatherine Larochelle
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MD, PhDNathalie Arbour
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
PhDAlexandre Prat
From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
MD, PhDCLMP Promotes Leukocyte Migration Across Brain Barriers in Multiple Sclerosis
Antoine Philippe Fournier, Stephanie Zandee, Marc Charabati, Evelyn Peelen, Olivier Tastet, Jorge Ivan Alvarez, Hania Kebir, Lyne Bourbonnière, Sandra Larouche, Boaz Lahav, Wendy Klement, Fiona Tea, Alain Bouthillier, Robert Moumdjian, Romain Cayrol, Pierre Duquette, Marc Girard, Catherine Larochelle, Nathalie Arbour, Alexandre Prat
Neurol Neuroimmunol Neuroinflamm Nov 2022, 9 (6) e200022; DOI: 10.1212/NXI.0000000000200022
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vol. 9 no. 6 e200022
PubMed:
Online ISSN:
History:
- Received February 23, 2022
- Accepted in final form June 10, 2022
- First Published September 9, 2022.
Copyright & Usage:
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
Author Disclosures
- Antoine Philippe Fournier, PhD,
- Stephanie Zandee, PhD,
- Marc Charabati, MSc,
- Evelyn Peelen, PhD,
- Olivier Tastet, MSc,
- Jorge Ivan Alvarez, PhD,
- Hania Kebir, PhD,
- Lyne Bourbonnière, MSc,
- Sandra Larouche,
- Boaz Lahav, Bsc,
- Wendy Klement, MSc,
- Fiona Tea, PhD,
- Alain Bouthillier, MD,
- Robert Moumdjian, MD,
- Romain Cayrol, MD, PhD,
- Pierre Duquette, MD,
- Marc Girard, MD,
- Catherine Larochelle, MD, PhD,
- Nathalie Arbour, PhD and
- Alexandre Prat, MD, PhD
- Antoine Philippe Fournier, PhD,
- Stephanie Zandee, PhD,
- Marc Charabati, MSc,
- Evelyn Peelen, PhD,
- Olivier Tastet, MSc,
- Jorge Ivan Alvarez, PhD,
- Hania Kebir, PhD,
- Lyne Bourbonnière, MSc,
- Sandra Larouche,
- Boaz Lahav, Bsc,
- Wendy Klement, MSc,
- Fiona Tea, PhD,
- Alain Bouthillier, MD,
- Robert Moumdjian, MD,
- Romain Cayrol, MD, PhD,
- Pierre Duquette, MD,
- Marc Girard, MD,
- Catherine Larochelle, MD, PhD,
- Nathalie Arbour, PhD and
- Alexandre Prat, MD, PhD
- From the Neuroimmunology Research Laboratory (A.P.F., S.Z., M.C., E.P., O.T., J.I.A., H.K., L.B., S.L., B., W.K., F.T., P.D., C.L., N.A., M.D.,P.D.A.P.), Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM); Department of Neurosciences (A.P.F., S.Z., M.C., E.P., F.T., C.L., N.A., M.D.,P.D.A.P.), Faculty of Medicine, Université de Montréal; Department of Microbiology (H.K.), Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal; Multiple Sclerosis Clinic (B., P.D., M.G., C.L., N.A., M.D.,P.D.A.P.), Division of Neurology, Centre Hospitalier de l'Université de Montréal (CHUM); Division of Neurosurgery (A.B., R.M.), Université de Montréal & CHUM; and Department of Pathology (R.C.), Université de Montréal & CHUM, Quebec, Canada.
- Correspondence
Dr. Prat a.prat{at}umontreal.ca
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