Seizure Semiology in Antibody-Associated Autoimmune Encephalitis
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Article Information
- Received February 2, 2022
- Accepted in final form August 8, 2022
- First Published October 20, 2022.
Author Disclosures
- Tillman Kaaden, MD*,
- Marie Madlener, MD,
- Klemens Angstwurm, MD,
- Christian G. Bien, MD,
- Yuri Bogarin, MD,
- Kathrin Doppler, MD,
- Alexander Finke, MD,
- Stefan T. Gerner, MD,
- Gernot Reimann, MD,
- Martin Häusler, MD,
- Robert Handreka, MD,
- Kerstin Hellwig, MD,
- Max Kaufmann, MD,
- Christoph Kellinghaus, MD,
- Peter Koertvelyessy, MD,
- Andrea Kraft, MD,
- Jan Lewerenz, MD,
- Til Menge, MD,
- Asterios Paliantonis, MD,
- Felix von Podewils, MD,
- Harald Prüss, MD,
- Sebastian Rauer, MD,
- Marius Ringelstein, MD,
- Kevin Rostásy, MD,
- Ingo Schirotzek, MD,
- Julia Schwabe, MD,
- Piotr Sokolowski, MD,
- Marie Suesse, MD,
- Kurt-Wolfram Sühs, MD,
- Rainer Surges, MD,
- Simone C. Tauber, MD,
- Franziska Thaler, MD,
- Florian Then Bergh, MD,
- Christian Urbanek, MD,
- Klaus-P. Wandinger, MD,
- Brigitte Wildemann, MD,
- Sigrid Mues, MD,
- Uwe Zettl, MD,
- Frank Leypoldt, MD,
- Nico Melzer, MD,
- Christian Geis, MD,
- Michael Malter, MD†,
- Albrecht Kunze, MD*,† and
- and the Generate study group
- Tillman Kaaden, MD*,
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- Marie Madlener, MD,
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- Klemens Angstwurm, MD,
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commercial entity, travel funding by Alexion, Bayer, BiogenIdec, MerckSerono,Novartis, and Teva in 2009 upto 2014; honoraria by Biogen and TEVA.
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Commercial entity: clinical studies on NMOSD for Alexion and Chugai, clinical studies on multiple sclerosis for Bayer, BiogenIdec, MerckSerono, Novartis, and Roche.
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- Christian G. Bien, MD,
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Research support from the Deutsche Forschungsgemeinschaft (German Research Council, Bonn, Germany: BI1254/9-1)
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Gerd-Altenhof-Stiftung (Deutsches Stiftungs-Zentrum, Essen, Germany: Essen - T0465/28102/2016/sm)
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- Yuri Bogarin, MD,
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- Kathrin Doppler, MD,
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(1)German Research Foundation, DO 2219/1-1, 2018-2021, DO 2219/2-1, 2021-2024 (2)Federal Ministry of Education and Research (BMBF), 2016-2019
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(1)International Parkinson Fonds, 2018-2021
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- Alexander Finke, MD,
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- Stefan T. Gerner, MD,
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- Gernot Reimann, MD,
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- Martin Häusler, MD,
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Medical Faculty, RWTH Aachen, Germany Digital University North-Rhine Westphalia, State of North- Rhine-Westphalia
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- Robert Handreka, MD,
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- Kerstin Hellwig, MD,
(1) Novartis (2) Genzyme (3) Teva (4) Merck (5) Roche (6) Jansen
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(1) Biogen, funding for travel (2) Novartis, funding for travel (3) Merck, funding for travel (4) Biogen Idec Germany, speaker honoraria (5) Teva, speaker honoraria (6) Sanofi Genzyme, speaker honoraria (7) Novartis, speaker honoraria (8) Bayer Healthcare, speaker honoraria (9) Merck Serono, speaker honoraria (10) Roche, speaker honoraria (11) BMS, speaker honoraria (12) Jansen, speaker honoraria
Editorial board N2 journal TAND associate editor
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Honoraria from Biogen, Bayer Healthcare, Teva, Sanofi, Merck, BMS, Jansen and Novartis
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Almiral, Biogen, Bayer Healthcare, Teva, Merck, Roche, Sanofi- Genzyme and Novartis
(1) Fund of the Federal Joint Committee
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- Max Kaufmann, MD,
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(1) Stifterverband (2) German Research Foundation (DFG)
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- Christoph Kellinghaus, MD,
(1) Eisai Co. (2) UCB Co. (3) GW Pharma Co. (4) Zogenix Co. (5) Neurocrine Biosciences, Inc. (6) Angelini Pharma Co.
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(1) UCB, speaker honoraria (2) Eisai, speaker honoraria (3) GW Pharma, speaker honoraria (4) Zogenix, speaker honoraria (5) Angelini Pharma, speaker honoraria
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- Peter Koertvelyessy, MD,
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- Andrea Kraft, MD,
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- Jan Lewerenz, MD,
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(1) Euroimmun, speaker's honoraria, 2014 (2) Teva, speaker's honoraria, 2016 (3) CHDI, travel,2018 (4) Movement Disorders Society, speaker's honoraria, 2018
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(1) JL oversees a laboratory of a non-profit hospital that offers testing for antineuronal and onconeuronal antibodies.
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- Til Menge, MD,
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Travel support from Merck Serono 2006, Bayer-Schering Pharma in 2007, Biogen in 2009-2019 and Teva in 2013-2014.
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Honoraria from Bayer-Schering Pharma and Merck Serono in 2008, Biogen in 2008-2022, Novartis in 2008-2022, Teva in 2008-2019, Roche 2015-2022, Genzyme in 2012-14 and BMS in 2020.
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- Asterios Paliantonis, MD,
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- Felix von Podewils, MD,
(1) GW Pharma: commercial entity (2) AngeliniPharma: commercial entity
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- Harald Prüss, MD,
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- Sebastian Rauer, MD,
Roche, Biogen, Merck Serono, Novartis, Sanofi-Aventis, Genzyme, Hexal, Pfizer, Valneva
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Roche, Biogen, Merck Serono, Novartis, Sanofi-Aventis, Genzyme, Hexal, Pfizer, Valneva
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founding member and nonexecutive director of ravo-Diagnostika GmbH Freiburg
Roche, Biogen, Merck Serono, Novartis, Sanofi-Aventis, Genzyme, Hexal, Pfizer, Valneva
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Bayer, BMBF, Biogen, Hertie-Stiftung, Merck-Serono, Novartis,
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- Marius Ringelstein, MD,
1. Roche Pharma GmbH, served on a national scientific advisory board. 2. Alexion Pharma GmbH, served on a national scientific advisory board.
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1. Alexion, speaking honorarium. 2. Roche,speaking honorarium and funding for travel to a conference. 3. Biogen Idec, funding for travel to a conference.
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1. Roche Pharma GmbH, served on a national and international scientific advisory board. 2. Alexion Pharma GmbH, served on a national scientific advisory board.
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- Kevin Rostásy, MD,
Scientific adviser on Fingolimod project-Novartis Scientific adviser Roche/Ocreviusstudy in Children
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Advisory Board Meeting Novartis and Merck 2017, 2018
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- Ingo Schirotzek, MD,
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- Julia Schwabe, MD,
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- Piotr Sokolowski, MD,
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Neurological diagnostic for German Organ Procurement Organization
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- Marie Suesse, MD,
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personal fees and grants from Merck Healthcare Deutschland and Bayer Vital GmbH, Biogen
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Landesförderinstitut Mecklenburg-Vorpommern Germany, material research support,2020
grant support from the University of Greifswald (Gerhard-Domagk fellowship).
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- Kurt-Wolfram Sühs, MD,
(1)Merck (2)Biogen (3)BristolMyersSquibb
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(1) Merck, funding for travel for conference (2) Biogen, Advisory Board Member (3) BristolMyersSquibb, Advisory Board
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Hannover Medical School Carl-Neuberg-Straße 1 30625 Germany Dept. Neurology
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- Rainer Surges, MD,
Arvelle, Angelini, Bial, Eisai, Novartis, Livanova, UCB Pharma, UnEEG
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Speaker honoraria and funding for travel from Arvelle, Angelini, Bial, Desitin, Eisai, Novartis, Livanova, UCB Pharma
Member of the editorial board of Epilepsy and Behavior Associate Editor of Epilepsia Open
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BMG, BMBF
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Boll Stiftung Kerpen
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- Simone C. Tauber, MD,
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DGNeurologie (German Society for Neurology), reviewer since 2020 Deutsche Forschungsgesellschaft, reviewer 2021
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served on the scientific advisory board for Roche and Merck and received travel and speaker honoraria from Novartis, Teva, Merck, Roche and Biogen
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- Franziska Thaler, MD,
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received grant support from Novartis Pharma GmbH
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received grant support from the Else-Kröner-Fresenius Foundation, received grant support from the Gemeinnützige Hertie Stiftung
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- Florian Then Bergh, MD,
Speaker honoraria and consultancy fees as a speaker and advisor from Actelion, Bayer Healthcare, Biogen, Merck Serono, Novartis, Roche, Sanofi Genzyme, and TEVA.
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Support to attend scientific meetings from Bayer Schering, Biogen, Merck, Novartis and Sanofi-Genzyme.
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Support for investigator-initiated trials from Actelion, Novartis. Travel support to present results at scientific meetings, through the employing institution, from Bayer Schering, Biogen, Merck, Novartis and Sanofi Genzyme.
German Federal Ministry of Research; Deutsche Forschungsgemeinschaft (DFG, federal research funding agency)
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- Christian Urbanek, MD,
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- Klaus-P. Wandinger, MD,
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- Brigitte Wildemann, MD,
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Brigitte Wildemann has received personal fees from Alexion, Bayer, Biogen, Roche
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Brigitte Wildemann reports grants from Deutsche Forschungsgemeinschaft, Bundesministerium für Forschung und Technologie, grants from Dietmar Hopp Stiftung, grants from Klaus Tschira Stiftung, grants from Merck
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- Sigrid Mues, MD,
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Pilot-Project Tele-Epileptology Ruhr: cooperation with the companies VISUS, MECECON, Panvision and Knappschaftkliniken Servive GmbH Planned Project itVideoRef: cooperation with the Company vCreate Ltd.
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Pilot Project Tele-Epileptology Ruhr: Funding by Werner- Richard Dr. Carl Dörken Foundation
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- Uwe Zettl, MD,
None
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Travel compensation for research meetings: (1) Aventis (2) Bayer (3) Biogen (4) Celgene Speakers fee: (1) Almirall (2) Alexion (3) Bayer (4) Biogen (5) Merck (6) Novartis (7) Roche (8) Teva
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- Frank Leypoldt, MD,
(1) Roche (2) Biogen (3) Alexion
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(1) Grifols (2) Biogen (3) Bayer (4) Roche (5) Alexion
Neurology: Neuroimmunology and Neuroinflammation
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Institute of Laboratory Medicine, University Hospital Schleswig- Holstein Campus Kiel, Germany, commercial antibody testing service, 20%
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(1) German Ministry of Education and Research (BMBF) Speaker, PI 2019 01GM1908A (2) German Research Council (GRC, DFG), PI, 2019 LE 3064/2-1
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- Nico Melzer, MD,
1. Advisory Boards, Alexion Pharmaceuticals, Germany
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1. Biogen Idec, honoraria for lecturing and travel expenses for attending meetings 2. GlaxoSmith Kline, honoraria for lecturing and travel expenses for attending meetings 3. Teva, honoraria for lecturing and travel expenses for attending meetings 4. Fresenius Medical Care, honoraria for lecturing and travel expenses for attending Meetings 5. Alexion Pharmaceuticals Germany, honoraria for lecturing and travel expenses for attending Meetings
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1. Consultancy, UCB Pharma, Germany
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1. Immunoadsorption, (5%), 3 years
1. Fresenius Medical Care 2. Diamed 3. Novartis
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- Christian Geis, MD,
(1) Roche (2) Alexion
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(1) Alexion, speaker honoraria
Journal of Neurology, Neuroinflammation, Neuroimmunology, Associate Editor, 2021
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(1) German ministry of education, from 2013 (2) German Research council, FOR3004, from 2019 (3) Schilling Foundation, from 2019
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- Michael Malter, MD†,
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UCB Pharma, EISAI: speaker honoraria
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(1) Deutsche Gesellschaft für Neurologie (DGN) (2) Deutsche Gesellschaft für klinische Neurophysiologie (DGKN) (3) Deutsche Gesellschaft für Neurointensiv und Notfallmedizin (DGNI) (4) Deutsche Gesellschaft für Epileptologie (DGfE)
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- Albrecht Kunze, MD*,† and
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- and the Generate study group
- From the Hans-Berger Department of Neurology (T.K., C.G., Albrecht Kunze), University Hospital Jena; Department of Neurology (Marie Madlener, Michael Malter), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neurology (K.A.), University of Regensburg; Department of Epileptology (Krankenhaus Mara) (C.G.B.), Bielefeld University, Medical School, Campus Bielefeld-Bethel; Department of Psychiatry and Psychotherapy (Y.B.), Asklepios Hospital Teupitz; Department of Neurology (K.D.), University of Würzburg; Department of Neurology (A.F.), Hospital Lüneburg; Department of Neurology (S.T.G.), University Hospital Erlangen; Department of Neurology (G.R.), Klinikum Dortmund; Department of Neuro-pediatrics (M.H.), RWTH University Hospital Aachen; Department of Neurology (R.H.), Carl-Thiem Klinikum Cottbus; Department of Neurology (K.H.), University of Bochum; Institut für Neuroimmunologie und Multiple Sklerose (M.K.), Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; Department of Neurology (C.K.), Klinikum Osnabrück; Department of Neurology (P.K.), University of Magdeburg; Department of Neurology (Andrea Kraft), Martha-Maria Hospital Halle; Department of Neurology (J.L.), University of Ulm; Department of Neurology (T.M., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf, Germany; Department of Neurology (A.P.), Klinikum Hirslanden, Zürich; Department of Neurology (F.v.P., M.S.), University of Greifswald; Department of Neurology and Experimental Neurology (H.P.), Charité Berlin, and German Center for Neurodegenerative Diseases (DZNE); Department of Neurology (S.R., N.M.), University of Freiburg; Department of Neurology (M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany; Department of Neuropediatrics (K.R.), Vestische Kinder-und Jugendklinik Datteln; Department of Neurology (I.S.), University Hospital Giessen and Marburg, Giessen; Department of Neurology (J.S.), Asklepios Hospital Nord, Hamburg; Department of Neurology (P.S.), Hospital Hubertusburg, Wermsdorf; Department of Neurology (K.-W.S.), University Hospital Hannover; Department of Epileptology (R.S.), University Hospital Bonn; Department of Neurology (S.C.T.), RWTH University Hospital Aachen; Institute of Clinical Neuroimmunology (F.T.), University Hospital, Ludwig-Maximilians-Universität Munich, Germany and Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (C.U.), Hospital Ludwigshafen; Institute of Clinical Chemistry (K.-P.W.), University Hospital Schleswig-Holstein, Kiel/Lübeck, Germany; Department of Neurology (B.W.), University of Heidelberg; Department of Neurology (S.M.), University Hospital, Technische Universität Dresden; Universitätsklinikum Knappschaftskrankenhaus Bochum Langendreer (S.M.), Klinik für Neurologie; Department of Neurology (U.Z.), University of Rostock; Department of Neurology (F.L.), Christian-Albrechts-University Kiel; Department of Neurology with Institute of Translational Neurology (N.M.), University Hospital Muenster; and Department of Neurology (Albrecht Kunze), Zentralklinik Bad Berka, Germany.
- Correspondence
Dr. Kaaden tillman.kaaden{at}med.uni-jena.de
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