Disclosures
Dennis L. Kolson , MD, PhD
| Editorial Boards | |
| Serving as an associate editor for Neurology: Neuroimmunology & Neuroinflammation | |
| Research Support, Government Entities | |
| 1R01 MH104134-01 (Kolson) 5/1/2014 – 4/30/19 NIH/NIMH Oxidative stress, immune activation and therapeutic targeting in HAND The goals are to determine the association between brain regional heme oxygenase deficiency and neurocognitive impairment in HIV infected individuals, and to determine whether the simian immunodeficiency virus (SIV) primate model for neuroAIDS can be used to assess heme oxygenase- targeted therapies. Role: (PI) Overlap: There is no scientific or budgetary overlap 1R01 MH111389-01 (Kolson) 8/18/16 – 5/31/21 NIH/NIMH Regulation of heme oxygenase in HIV/HAND pathogenesis The goals are to define the potential neuropathogenic role for a common heme oxygenase-1 promoter dinucleotide (GT)n repeat in the dysregulation of heme oxygenase-1 expression in HIV-infected individuals and determine the associated mechanisms of blood-brain barrier dysfunction. Role: (PI) Overlap: There is no scientific or budgetary overlap 1R01NS101156-01A1: (Talos) 1/01/2018-12/31/2023 NIH/NINDS The role of oxidative stress and inflammation in epileptogenesis The goals are to investigate specific blood and brain tissue biomarkers of inflammation and oxidative stress in mouse models of epileptogenesis, and to test novel neuroprotective strategies to prevent the development of chronic epilepsy and/or its neuropsychiatric co-morbidities. Role: Co-I Overlap: There is no scientific or budgetary overlap 1P30MH097488-01A1: (Evans) 6/03/13 - 05/31/18 NIH/NIMH Penn mental health AIDS research center This Center will specifically focus on the combination of mental illness and HIV/AIDS and related comorbidities to develop innovative, integrated treatments to optimize psychiatric, behavioral, and medical outcomes and to achieve a better understanding of the biological, psychological, and behavioral mechanisms underlying these combined illnesses and treatments. Dr. Kolson serves as consultant and scientific advisor for studies of HIV- associated neurocogntive disorders (HAND) and their relationship to psychiatric illnesses. Role: Co-I Overlap: There is no scientific or budgetary overlap | |