RT Journal Article
SR Electronic
T1 Is <em>APOE</em> ε4 associated with cognitive performance in early MS?
JF Neurology - Neuroimmunology Neuroinflammation
JO Neurol Neuroimmunol Neuroinflamm
FD Lippincott Williams &amp; Wilkins
SP e728
DO 10.1212/NXI.0000000000000728
VO 7
IS 4
A1 Engel, Sinah
A1 Graetz, Christiane
A1 Salmen, Anke
A1 Muthuraman, Muthuraman
A1 Toenges, Gerrit
A1 Ambrosius, Björn
A1 Bayas, Antonios
A1 Berthele, Achim
A1 Heesen, Christoph
A1 Klotz, Luisa
A1 Kümpfel, Tania
A1 Linker, Ralf A.
A1 Meuth, Sven G.
A1 Paul, Friedemann
A1 Stangel, Martin
A1 Tackenberg, Björn
A1 Then Bergh, Florian
A1 Tumani, Hayrettin
A1 Weber, Frank
A1 Wildemann, Brigitte
A1 Zettl, Uwe K.
A1 Antony, Gisela
A1 Bittner, Stefan
A1 Groppa, Sergiu
A1 Hemmer, Bernhard
A1 Wiendl, Heinz
A1 Gold, Ralf
A1 Zipp, Frauke
A1 Lill, Christina M.
A1 Luessi, Felix
A1 for the German Competence Network of Multiple Sclerosis
YR 2020
UL http://nn.neurology.org/content/7/4/e728.abstract
AB Objective To assess the impact of APOE polymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS).Methods This multicenter cohort study included 552 untreated patients recently diagnosed with CIS or RRMS according to the 2005 revised McDonald criteria. The single nucleotide polymorphisms rs429358 (ε4) and rs7412 (ε2) of the APOE haplotype were assessed by allelic discrimination assays. Cognitive performance was evaluated using the 3-second paced auditory serial addition test and the Multiple Sclerosis Inventory Cognition (MUSIC). Sum scores were calculated to approximate the overall cognitive performance and memory-centered cognitive functions. The impact of the APOE carrier status on cognitive performance was assessed using multiple linear regression models, also including demographic, clinical, MRI, and lifestyle factors.Results APOE ε4 homozygosity was associated with lower overall cognitive performance, whereas no relevant association was observed for APOE ε4 heterozygosity or APOE ε2 carrier status. Furthermore, higher disability levels, MRI lesion load, and depressive symptoms were associated with lower cognitive performance. Patients consuming alcohol had higher test scores than patients not consuming alcohol. Female sex, lower disability, and alcohol consumption were associated with better performance in the memory-centered subtests of MUSIC, whereas no relevant association was observed for APOE carrier status.Conclusion Along with parameters of a higher disease burden, APOE ε4 homozygosity was identified as a potential predictor of cognitive performance in this large cohort of patients with CIS and early RRMS.AD=Alzheimer disease; BDI-II=Beck Depression Inventory II; BMI=body mass index; CIS=clinically isolated syndrome; EDSS=Expanded Disability Status Scale; FSMC=Fatigue Scale for Motor and Cognitive Function; HWE=Hardy-Weinberg equilibrium; MCI=mild cognitive impairment; MUSIC=Multiple Sclerosis Inventory Cognition; PASAT 3=3-second paced auditory serial addition test; RRMS=relapsing-remitting MS; SNP=single nucleotide polymorphism