RT Journal Article
SR Electronic
T1 CSF chitinase 3-like-1 association with disability of primary progressive MS
JF Neurology - Neuroimmunology Neuroinflammation
JO Neurol Neuroimmunol Neuroinflamm
FD Lippincott Williams & Wilkins
SP e815
DO 10.1212/NXI.0000000000000815
VO 7
IS 5
A1 Francisco Pérez-Miralles
A1 Daniel Prefasi
A1 Antonio García-Merino
A1 Francisco Gascón-Giménez
A1 Nicolás Medrano
A1 Jessica Castillo-Villalba
A1 Laura Cubas
A1 Carmen Alcalá
A1 Sara Gil-Perotín
A1 Rocío Gómez-Ballesteros
A1 Jorge Maurino
A1 Esther Álvarez-García
A1 Bonaventura Casanova
YR 2020
UL http://nn.neurology.org/content/7/5/e815.abstract
AB Objective To assess the role of CSF chitinase 3-like-1 (CHI3L1), chitinase 3-like-2 (CHI3L2), and neurofilament light chain (NfL) in predicting the course of primary progressive MS (PPMS).Methods We analyzed CSF CHI3L1, CHI3L2, and NfL levels in 25 patients with PPMS with disease duration ≤10 years and no disease-modifying therapy for ≥6 months from the prospective Understanding Primary Progressive Multiple Sclerosis cohort study. CSF samples taken at disease diagnosis were analyzed using commercial ELISAs and following the manufacturer's instructions. Data on Expanded Disability Status Scale (EDSS) scores, disability progression, and cognitive function according to the Brief Repeatable Neuropsychological Battery were also assessed throughout the 1-year study follow-up.Results Increasing CHI3L1 levels correlated with higher EDSS scores at baseline (ρ = 0.490, 95% CI 0.118–0.742, p = 0.013) and month 12 (ρ = 0.455, 95% CI 0.063–0.725, p = 0.026) and tended to be associated with a higher risk of disability progression according to EDSS scores (OR = 1.008, 95% CI 0.999–1.017, p = 0.089). Increasing CHI3L2 levels also tended to correlate with lower baseline EDSS scores (ρ = −0.366, 95% CI -0.676–0.054, p = 0.086). There was no correlation with regard to NfL levels.Conclusions This analysis supports the association between CSF CHI3L1 levels and neurologic disability according to EDSS scores in patients with PPMS. Other chitinase-like proteins such as CHI3L2 may also be involved.Classification of evidence This study provides Class II evidence that CSF CHI3L1 is associated with neurologic disability in patients with PPMS.9-HPT=9-Hole Peg Test; CHI3L1=chitinase 3-like-1; CHI3L2=chitinase 3-like-2; CIS=clinically isolated syndrome; EDSS=Expanded Disability Status Scale; NfL=neurofilament light chain; PPMS=primary progressive MS; T25-fw=Timed 25-Foot Walk; UPPMS=Understanding Primary Progressive Multiple Sclerosis