RT Journal Article
SR Electronic
T1 COVID-19 outcomes in MS
JF Neurology - Neuroimmunology Neuroinflammation
JO Neurol Neuroimmunol Neuroinflamm
FD Lippincott Williams & Wilkins
SP e835
DO 10.1212/NXI.0000000000000835
VO 7
IS 5
A1 Parrotta, Erica
A1 Kister, Ilya
A1 Charvet, Leigh
A1 Sammarco, Carrie
A1 Saha, Valerie
A1 Charlson, Robert Erik
A1 Howard, Jonathan
A1 Gutman, Josef Maxwell
A1 Gottesman, Malcolm
A1 Abou-Fayssal, Nada
A1 Wolintz, Robyn
A1 Keilson, Marshall
A1 Fernandez-Carbonell, Cristina
A1 Krupp, Lauren B.
A1 Zhovtis Ryerson, Lana
YR 2020
UL http://nn.neurology.org/content/7/5/e835.abstract
AB Objective To report outcomes on patients with multiple sclerosis (MS) and related disorders with coronavirus disease 2019 (COVID-19) illness.Methods From March 16 to April 30, 2020, patients with MS or related disorders at NYU Langone MS Comprehensive Care Center were identified with laboratory-confirmed or suspected COVID-19. The diagnosis was established using a standardized questionnaire or by review of in-patient hospital records.Results We identified 76 patients (55 with relapsing MS, of which 9 had pediatric onset; 17 with progressive MS; and 4 with related disorders). Thirty-seven underwent PCR testing and were confirmed positive. Of the entire group, 64 (84%) patients were on disease-modifying therapy (DMT) including anti-CD20 therapies (n = 34, 44.7%) and sphingosine-1-phosphate receptor modulators (n = 10, 13.5%). The most common COVID-19 symptoms were fever and cough, but 21.1% of patients had neurologic symptom recrudescence preceding or coinciding with the infection. A total of 18 (23.7%) were hospitalized; 8 (10.5%) had COVID-19 critical illness or related death. Features more common among those hospitalized or with critical illness or death were older age, presence of comorbidities, progressive disease, and a nonambulatory status. No DMT class was associated with an increased risk of hospitalization or fatal outcome.Conclusions Most patients with MS with COVID-19 do not require hospitalization despite being on DMTs. Factors associated with critical illness were similar to the general at-risk patient population. DMT use did not emerge as a predictor of poor COVID-19 outcome in this preliminary sample.CAD=coronary artery disease; COVID-19=coronavirus disease 2019; DMT=disease-modifying therapy; ICU=intensive care unit