RT Journal Article
SR Electronic
T1 Autoimmune Neurology
JF Neurology - Neuroimmunology Neuroinflammation
JO Neurol Neuroimmunol Neuroinflamm
FD Lippincott Williams & Wilkins
SP e1033
DO 10.1212/NXI.0000000000001033
VO 8
IS 5
A1 Justin R. Abbatemarco
A1 Stefanie J. Rodenbeck
A1 Gregory S. Day
A1 Maarten J. Titulaer
A1 Anusha K. Yeshokumar
A1 Stacey L. Clardy
YR 2021
UL http://nn.neurology.org/content/8/5/e1033.abstract
AB Autoimmune neurology is a rapidly developing specialty driven by an increasing recognition of autoimmunity as the cause for a broad set of neurologic disorders and ongoing discovery of new neural autoantibodies associated with recognizable clinical syndromes. The diversity of clinical presentations, unique pathophysiology, and the complexity of available treatments requires a dedicated multidisciplinary team to diagnose and manage patients. In this article, we focus on antibody-associated autoimmune encephalitis (AE) to illustrate broader themes applicable to the specialty. We discuss common diagnostic challenges including the utilization of clinical assessment tools along with the determination of the prognostic significance of certain autoantibodies, with a focus on implications for long-term management. A growing body of literature demonstrates the long-term cognitive, behavioral, and physical sequelae of AE. Dedicated resources are needed to effectively manage these patients. These resources may be best provided by experienced neurology clinics in partnership with other neurologic subspecialists, as well as psychiatrists, neuropsychologists, and physical medicine and rehabilitation providers.AE=autoimmune encephalitis; AED=antiepileptic drug; CASE=Clinical Assessment Scale in Autoimmune Encephalitis; ICU=intensive care unit; LGI-1=leucine-rich, glioma-inactivated 1; mRS=modified Rankin Scale; NEOS=NMDAR Encephalitis One-Year Functional Status; NMDAR=NMDA receptor