RT Journal Article
SR Electronic
T1 Retinal Optical Coherence Tomography in Neuromyelitis Optica
JF Neurology - Neuroimmunology Neuroinflammation
JO Neurol Neuroimmunol Neuroinflamm
FD Lippincott Williams & Wilkins
SP e1068
DO 10.1212/NXI.0000000000001068
VO 8
IS 6
A1 Oertel, Frederike Cosima
A1 Specovius, Svenja
A1 Zimmermann, Hanna G.
A1 Chien, Claudia
A1 Motamedi, Seyedamirhosein
A1 Bereuter, Charlotte
A1 Cook, Lawrence
A1 Lana Peixoto, Marco Aurélio
A1 Fontanelle, Mariana Andrade
A1 Kim, Ho Jin
A1 Hyun, Jae-Won
A1 Palace, Jacqueline
A1 Roca-Fernandez, Adriana
A1 Leite, Maria Isabel
A1 Sharma, Srilakshmi
A1 Ashtari, Fereshteh
A1 Kafieh, Rahele
A1 Dehghani, Alireza
A1 Pourazizi, Mohsen
A1 Pandit, Lekha
A1 D'Cunha, Anitha
A1 Aktas, Orhan
A1 Ringelstein, Marius
A1 Albrecht, Philipp
A1 May, Eugene
A1 Tongco, Caryl
A1 Leocani, Letizia
A1 Pisa, Marco
A1 Radaelli, Marta
A1 Martinez-Lapiscina, Elena H.
A1 Stiebel-Kalish, Hadas
A1 Siritho, Sasitorn
A1 de Seze, Jérome
A1 Senger, Thomas
A1 Havla, Joachim
A1 Marignier, Romain
A1 Calvo, Alvaro Cobo
A1 Bichuetti, Denis
A1 Tavares, Ivan Maynart
A1 Asgari, Nasrin
A1 Soelberg, Kerstin
A1 Altintas, Ayse
A1 Yildirim, Rengin
A1 Tanriverdi, Uygur
A1 Jacob, Anu
A1 Huda, Saif
A1 Rimler, Zoe
A1 Reid, Allyson
A1 Mao-Draayer, Yang
A1 Soto de Castillo, Ibis
A1 Petzold, Axel
A1 Green, Ari J.
A1 Yeaman, Michael R.
A1 Smith, Terry
A1 Brandt, Alexander U.
A1 Paul, Friedemann
YR 2021
UL http://nn.neurology.org/content/8/6/e1068.abstract
AB Background and Objectives To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) in a large international cohort after previous studies have been limited by small and heterogeneous cohorts.Methods The cross-sectional Collaborative Retrospective Study on retinal optical coherence tomography (OCT) in neuromyelitis optica collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG–seropositive patients with NMOSD and 72 healthy controls (HCs). Participants underwent OCT with central reading including quality control and intraretinal segmentation. The primary outcome was thickness of combined ganglion cell and inner plexiform (GCIP) layer; secondary outcomes were thickness of peripapillary retinal nerve fiber layer (pRNFL) and visual acuity (VA).Results Eyes with ON (NMOSD-ON, N = 260) or without ON (NMOSD-NON, N = 241) were assessed compared with HCs (N = 136). In NMOSD-ON, GCIP layer (57.4 ± 12.2 μm) was reduced compared with HC (GCIP layer: 81.4 ± 5.7 μm, p < 0.001). GCIP layer loss (−22.7 μm) after the first ON was higher than after the next (−3.5 μm) and subsequent episodes. pRNFL observations were similar. NMOSD-NON exhibited reduced GCIP layer but not pRNFL compared with HC. VA was greatly reduced in NMOSD-ON compared with HC eyes, but did not differ between NMOSD-NON and HC.Discussion Our results emphasize that attack prevention is key to avoid severe neuroaxonal damage and vision loss caused by ON in NMOSD. Therapies ameliorating attack-related damage, especially during a first attack, are an unmet clinical need. Mild signs of neuroaxonal changes without apparent vision loss in ON-unaffected eyes might be solely due to contralateral ON attacks and do not suggest clinically relevant progression but need further investigation.AQP4-IgG=aquaporin-4 IgG; CROCTINO=Collaborative Retrospective Study on retinal OCT in Neuromyelitis Optica; EDSS=Expanded Disability Status Scale; GCIP=ganglion cell and inner plexiform; HC=healthy control; HC-VA=high-contrast visual acuity; INL=inner nuclear layer; MME=microcystic macular edema; MS=multiple sclerosis; MOG-IgG=myelin oligodendrocyte glycoprotein IgG; NMOSD=neuromyelitis optica spectrum disorder; NMOSD-NON=NMOSD eyes without a history of ON; OCT=optical coherence tomography; ON=optic neuritis; pRNFL=peripapillary retinal nerve fiber layer; SE=standard error; VA=visual acuity; VEP=visually evoked potential