RT Journal Article
SR Electronic
T1 Multiple Sclerosis Followed by Neuromyelitis Optica Spectrum Disorder
JF Neurology - Neuroimmunology Neuroinflammation
JO Neurol Neuroimmunol Neuroinflamm
FD Lippincott Williams & Wilkins
SP e200037
DO 10.1212/NXI.0000000000200037
VO 10
IS 1
A1 Carolyn Goldschmidt
A1 Steven L. Galetta
A1 Robert P. Lisak
A1 Laura J. Balcer
A1 Andrew Hellman
A1 Michael K. Racke
A1 Amy E. Lovett-Racke
A1 Roberto Cruz
A1 Matthew S. Parsons
A1 Neda Sattarnezhad
A1 Lawrence Steinman
A1 Scott S. Zamvil
A1 Elliot M. Frohman
A1 Teresa C. Frohman
YR 2023
UL http://nn.neurology.org/content/10/1/e200037.abstract
AB A woman presented at age 18 years with partial myelitis and diplopia and experienced multiple subsequent relapses. Her MRI demonstrated T2 abnormalities characteristic of multiple sclerosis (MS) (white matter ovoid lesions and Dawson fingers), and CSF demonstrated an elevated IgG index and oligoclonal bands restricted to the CSF. Diagnosed with clinically definite relapsing-remitting MS, she was treated with various MS disease-modifying therapies and eventually began experiencing secondary progression. At age 57 years, she developed an acute longitudinally extensive transverse myelitis and was found to have AQP4 antibodies by cell-based assay. Our analysis of the clinical course, radiographic findings, molecular diagnostic methods, and treatment response characteristics support the hypothesis that our patient most likely had 2 CNS inflammatory disorders: MS, which manifested as a teenager, and neuromyelitis optica spectrum disorder, which evolved in her sixth decade of life. This case emphasizes a key principle in neurology practice, which is to reconsider whether the original working diagnosis remains tenable, especially when confronted with evidence (clinical and/or paraclinical) that raises the possibility of a distinctively different disorder.DMT=disease-modifying therapy; MS=multiple sclerosis; NMOSD=neuromyelitis optica spectrum disorder; RRMS=relapsing-remitting MS; S-1-P=sphingosine-1-phosphate; SPMS=secondary progressive MS; UTI=urinary tract infection