PT  - JOURNAL ARTICLE
AU  - Rival, Manon
AU  - Thouvenot, Eric
AU  - Du Trieu de Terdonck, Lucile
AU  - Laurent-Chabalier, Sabine
AU  - Demattei, Christophe
AU  - Uygunoglu, Ugur
AU  - Castelnovo, Giovanni
AU  - Cohen, Mikael
AU  - Okuda, Darin T.
AU  - Kantarci, Orhun H.
AU  - Pelletier, Daniel
AU  - Azevedo, Christina
AU  - Marin, Philippe
AU  - Lehmann, Sylvain
AU  - Siva, Aksel
AU  - Mura, Thibault
AU  - Lebrun-Frenay, Christine
ED  - ,
TI  - Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome
AID  - 10.1212/NXI.0000000000200044
DP  - 2023 Jan 01
TA  - Neurology - Neuroimmunology Neuroinflammation
PG  - e200044
VI  - 10
IP  - 1
4099  - http://nn.neurology.org/content/10/1/e200044.short
4100  - http://nn.neurology.org/content/10/1/e200044.full
SO  - Neurol Neuroimmunol Neuroinflamm2023 Jan 01; 10
AB  - Background and Objectives To evaluate the predictive value of serum neurofilament light chain (sNfL) and CSF NfL (cNfL) in patients with radiologically isolated syndrome (RIS) for evidence of disease activity (EDA) and clinical conversion (CC).Methods sNfL and cNfL were measured at RIS diagnosis by single-molecule array (Simoa). The risk of EDA and CC according to sNfL and cNfL was evaluated using the Kaplan-Meier analysis and multivariate Cox regression models including age, spinal cord (SC) or infratentorial lesions, oligoclonal bands, CSF chitinase 3–like protein 1, and CSF white blood cells.Results Sixty-one patients with RIS were included. At diagnosis, sNfL and cNfL were correlated (Spearman r = 0.78, p < 0.001). During follow-up, 47 patients with RIS showed EDA and 36 patients showed CC (median time 12.6 months, 1–86). When compared with low levels, medium and high cNfL (>260 pg/mL) and sNfL (>5.0 pg/mL) levels were predictive of EDA (log rank, p < 0.01 and p = 0.02, respectively). Medium-high cNfL levels were predictive of CC (log rank, p < 0.01). In Cox regression models, cNfL and sNfL were independent factors of EDA, while SC lesions, cNfL, and sNfL were independent factors of CC.Discussion cNfL >260 pg/mL and sNfL >5.0 pg/mL at diagnosis are independent predictive factors of EDA and CC in RIS. Although cNfL predicts disease activity better, sNfL is more accessible than cNfL and can be considered when a lumbar puncture is not performed.Classification of Evidence This study provides Class II evidence that in people with radiologic isolated syndrome (RIS), initial serum and CSF NfL levels are associated with subsequent evidence of disease activity or clinical conversion.AUC=area under the curve; CC=clinical conversion; CHI3L1=CSF chitinase 3–like protein 1; DIS=dissemination in space; EDA=evidence of disease activity; MS=multiple sclerosis; NEDA=nonevidence of disease activity; OCBs=oligoclonal bands; RIS=radiologically isolated syndrome; RRMS=relapsing-remitting MS; sNfL=serum neurofilament light chain; SC=spinal cord