RT Journal Article
SR Electronic
T1 MOG Antibody–Associated Disease and Thymic Hyperplasia
JF Neurology - Neuroimmunology Neuroinflammation
JO Neurol Neuroimmunol Neuroinflamm
FD Lippincott Williams & Wilkins
SP e200077
DO 10.1212/NXI.0000000000200077
VO 10
IS 2
A1 Brigitte Hurtubise
A1 Elliot M. Frohman
A1 Steven Galetta
A1 Laura J. Balcer
A1 Teresa C. Frohman
A1 Robert P. Lisak
A1 Scott D. Newsome
A1 Jennifer S. Graves
A1 Scott S. Zamvil
A1 Lilyana Amezcua
YR 2023
UL http://nn.neurology.org/content/10/2/e200077.abstract
AB Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell–dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic hyperplasia can be associated with certain autoimmune diseases. In this report we describe a case of MOGAD associated with thymic hyperplasia in a young adult.Ab=antibody; AQP4=aquaporin 4 antibody; CRION=chronic relapsing inflammatory ON; CRP=C-reactive protein; ED=emergency department; ESR=erythrocyte sedimentation rate; FLAIR=fluid-attenuated inversion recovery; IgG=immunoglobulin G; IV-MP=IV methylprednisolone; MOG=myelin oligodendrocyte glycoprotein; MOGAD=MOG antibody–associated disease; NMOSD=neuromyelitis optica spectrum disorders; NMO=neuromyelitis optica; ON=optic neuritis; TLH=thymic lymphocytic hyperplasia