PT  - JOURNAL ARTICLE
AU  - Kaminie Moodley
AU  - Pierre L.A. Bill
AU  - Vinod Bhagu Patel
TI  - A comparative study of CIDP in a cohort of HIV-infected and HIV-uninfected patients
AID  - 10.1212/NXI.0000000000000315
DP  - 2017 Mar 01
TA  - Neurology - Neuroimmunology Neuroinflammation
PG  - e315
VI  - 4
IP  - 2
4099  - http://nn.neurology.org/content/4/2/e315.short
4100  - http://nn.neurology.org/content/4/2/e315.full
SO  - Neurol Neuroimmunol Neuroinflamm2017 Mar 01; 4
AB  - Objective: To investigate differences in clinical presentation, electrodiagnostic measures, CSF changes, and treatment outcome measures in HIV-infected and HIV-uninfected patients with chronic inflammatory demyelinating polyneuropathy (CIDP).Methods: A retrospective analysis of medical records of all patients meeting the European Federation of Neurology diagnostic criteria for idiopathic CIDP was performed in 2 neuromuscular units in Kwa-Zulu Natal between 2003 and 2015.Results: Eighty-four patients were included in the study; 39 were HIV-infected and 45 were HIV-uninfected. Among the HIV-infected patients, the majority were younger, were female, and had a monophasic progressive illness. Eighty-six percent (86%) were corticosteroid-responsive and 76% were in remission within 6–12 months requiring no further treatment. Among the HIV- uninfected patients, the majority were older, were male, and had a relapsing-remitting course. Twenty-seven percent (27%) were corticosteroid-responsive, 95% required combination therapy, and 33% were not in remission by 18 months on therapy.Conclusion: This study shows that HIV-infected patients with CIDP were younger, were more often female, displayed a monophasic progressive course, were highly steroid-responsive, and went into remission within 12 months of corticosteroid initiation.AIDP=acute inflammatory demyelinating polyneuropathy; ART=antiretroviral therapy; BMI=body mass index; CIDP=chronic inflammatory demyelinating polyneuropathy; ENFS=European Federation of Neurologic Sciences; IALCH=Inkosi Albert Luthuli Central Hospital; INCAT=Inflammatory Neuropathy Cause and Treatment; IQR=interquartile range; IRIS=immune reconstitution inflammatory syndrome; IVIg=IV immunoglobulin; KZN=Kwa-Zulu Natal; ODSS=Overall Disability Sum Score; PNS=Peripheral Nerve Society; T2 DM=type 2 diabetes mellitus