PT  - JOURNAL ARTICLE
AU  - Hacohen, Yael
AU  - Absoud, Michael
AU  - Deiva, Kumaran
AU  - Hemingway, Cheryl
AU  - Nytrova, Petra
AU  - Woodhall, Mark
AU  - Palace, Jacqueline
AU  - Wassmer, Evangeline
AU  - Tardieu, Marc
AU  - Vincent, Angela
AU  - Lim, Ming
AU  - Waters, Patrick
TI  - Myelin oligodendrocyte glycoprotein antibodies are associated with a non-MS course in children
AID  - 10.1212/NXI.0000000000000081
DP  - 2015 Apr 01
TA  - Neurology - Neuroimmunology Neuroinflammation
PG  - e81
VI  - 2
IP  - 2
4099  - http://nn.neurology.org/content/2/2/e81.short
4100  - http://nn.neurology.org/content/2/2/e81.full
SO  - Neurol Neuroimmunol Neuroinflamm2015 Apr 01; 2
AB  - Objective: To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS).Method: Sixty-five children with a first episode of ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 transverse myelitis, 11 other clinically isolated syndrome) were identified from 2 national demyelination programs in the United Kingdom and France. Acute serum samples were tested for MOG-Abs by cell-based assay. Antibodies were used to predict diagnosis of multiple sclerosis (MS) at 1 year.Results: Twenty-three of 65 (35%) children had MOG-Abs. Antibody-positive and antibody-negative patients were not clinically different at presentation, but identification of MOG-Abs predicted a non-MS course at 1-year follow-up: only 2/23 (9%) MOG-Ab–positive patients were diagnosed with MS compared to 16/42 (38%) MOG-Ab–negative patients (p = 0.019, Fisher exact test). Antibody positivity at outset was a useful predictor for a non-MS disease course, with a positive predictive value of 91% (95% confidence interval [CI] 72–99), negative predictive value of 38% (95% CI 24–54), positive likelihood ratio of 4.02 (CI 1.0–15.4), and odds ratio of 6.5 (CI 1.3–31.3).Conclusions: MOG-Abs are found at presentation in 35% of patients with childhood ADS, across a range of demyelinating disorders. Antibody positivity can be useful in predicting a non-MS disease course at onset.Ab=antibody; ADEM=acute disseminated encephalomyelitis; ADS=acquired demyelinating syndrome; AQP4=aquaporin-4; CBA=cell-based assay; CI=confidence interval; CIS=clinically isolated syndrome; IVIg=IV immunoglobulin; MOG=myelin oligodendrocyte glycoprotein; MS=multiple sclerosis; NMO=neuromyelitis optica; NMOSD=NMO spectrum disorder; OCB=oligoclonal band; OR=odds ratio