PT - JOURNAL ARTICLE AU - Hacohen, Yael AU - Absoud, Michael AU - Deiva, Kumaran AU - Hemingway, Cheryl AU - Nytrova, Petra AU - Woodhall, Mark AU - Palace, Jacqueline AU - Wassmer, Evangeline AU - Tardieu, Marc AU - Vincent, Angela AU - Lim, Ming AU - Waters, Patrick TI - Myelin oligodendrocyte glycoprotein antibodies are associated with a non-MS course in children AID - 10.1212/NXI.0000000000000081 DP - 2015 Apr 01 TA - Neurology - Neuroimmunology Neuroinflammation PG - e81 VI - 2 IP - 2 4099 - http://nn.neurology.org/content/2/2/e81.short 4100 - http://nn.neurology.org/content/2/2/e81.full SO - Neurol Neuroimmunol Neuroinflamm2015 Apr 01; 2 AB - Objective: To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS).Method: Sixty-five children with a first episode of ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 transverse myelitis, 11 other clinically isolated syndrome) were identified from 2 national demyelination programs in the United Kingdom and France. Acute serum samples were tested for MOG-Abs by cell-based assay. Antibodies were used to predict diagnosis of multiple sclerosis (MS) at 1 year.Results: Twenty-three of 65 (35%) children had MOG-Abs. Antibody-positive and antibody-negative patients were not clinically different at presentation, but identification of MOG-Abs predicted a non-MS course at 1-year follow-up: only 2/23 (9%) MOG-Ab–positive patients were diagnosed with MS compared to 16/42 (38%) MOG-Ab–negative patients (p = 0.019, Fisher exact test). Antibody positivity at outset was a useful predictor for a non-MS disease course, with a positive predictive value of 91% (95% confidence interval [CI] 72–99), negative predictive value of 38% (95% CI 24–54), positive likelihood ratio of 4.02 (CI 1.0–15.4), and odds ratio of 6.5 (CI 1.3–31.3).Conclusions: MOG-Abs are found at presentation in 35% of patients with childhood ADS, across a range of demyelinating disorders. Antibody positivity can be useful in predicting a non-MS disease course at onset.Ab=antibody; ADEM=acute disseminated encephalomyelitis; ADS=acquired demyelinating syndrome; AQP4=aquaporin-4; CBA=cell-based assay; CI=confidence interval; CIS=clinically isolated syndrome; IVIg=IV immunoglobulin; MOG=myelin oligodendrocyte glycoprotein; MS=multiple sclerosis; NMO=neuromyelitis optica; NMOSD=NMO spectrum disorder; OCB=oligoclonal band; OR=odds ratio