PT  - JOURNAL ARTICLE
AU  - Bakshi, Rohit
AU  - Yeste, Ada
AU  - Patel, Bonny
AU  - Tauhid, Shahamat
AU  - Tummala, Subhash
AU  - Rahbari, Roya
AU  - Chu, Renxin
AU  - Regev, Keren
AU  - Kivisäkk, Pia
AU  - Weiner, Howard L.
AU  - Quintana, Francisco J.
TI  - Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis
AID  - 10.1212/NXI.0000000000000200
DP  - 2016 Apr 01
TA  - Neurology - Neuroimmunology Neuroinflammation
PG  - e200
VI  - 3
IP  - 2
4099  - http://nn.neurology.org/content/3/2/e200.short
4100  - http://nn.neurology.org/content/3/2/e200.full
SO  - Neurol Neuroimmunol Neuroinflamm2016 Apr 01; 3
AB  - Objective: To determine whether peripheral immune responses as measured by serum antigen arrays are linked to cerebral MRI measures of disease severity in multiple sclerosis (MS).Methods: In this cross-sectional study, serum samples were obtained from patients with relapsing-remitting MS (n = 21) and assayed using antigen arrays that contained 420 antigens including CNS-related autoantigens, lipids, and heat shock proteins. Normalized compartment-specific global brain volumes were obtained from 3-tesla MRI as surrogates of atrophy, including gray matter fraction (GMF), white matter fraction (WMF), and total brain parenchymal fraction (BPF). Total brain T2 hyperintense lesion volume (T2LV) was quantified from fluid-attenuated inversion recovery images.Results: We found serum antibody patterns uniquely correlated with BPF, GMF, WMF, and T2LV. Furthermore, we identified immune signatures linked to MRI markers of neurodegeneration (BPF, GMF, WMF) that differentiated those linked to T2LV. Each MRI measure was correlated with a specific set of antibodies. Strikingly, immunoglobulin G (IgG) antibodies to lipids were linked to brain MRI measures. Based on the association between IgG antibody reactivity and each unique MRI measure, we developed a lipid index. This comprised the reactivity directed against all of the lipids associated with each specific MRI measure. We validated these findings in an additional independent set of patients with MS (n = 14) and detected a similar trend for the correlations between BPF, GMF, and T2LV vs their respective lipid indexes.Conclusions: We propose serum antibody repertoires that are associated with MRI measures of cerebral MS involvement. Such antibodies may serve as biomarkers for monitoring disease pathology and progression.BPF=brain parenchymal fraction; GM=gray matter; GMF=gray matter fraction; IgG=immunoglobulin G; MS=multiple sclerosis; T2LV=T2 hyperintense lesion volume; WM=white matter; WMF=white matter fraction