RT Journal Article
SR Electronic
T1 Insufficient treatment of severe depression in neuromyelitis optica spectrum disorder
JF Neurology - Neuroimmunology Neuroinflammation
JO Neurol Neuroimmunol Neuroinflamm
FD Lippincott Williams & Wilkins
SP e286
DO 10.1212/NXI.0000000000000286
VO 3
IS 6
A1 Chavarro, Velina S.
A1 Mealy, Maureen A.
A1 Simpson, Alexandra
A1 Lacheta, Anna
A1 Pache, Florence
A1 Ruprecht, Klemens
A1 Gold, Stefan M.
A1 Paul, Friedemann
A1 Brandt, Alexander Ulrich
A1 Levy, Michael
YR 2016
UL http://nn.neurology.org/content/3/6/e286.abstract
AB Objective: To investigate depression frequency, severity, current treatment, and interactions with somatic symptoms among patients with neuromyelitis optica spectrum disorder (NMOSD).Methods: In this dual-center observational study, we included 71 patients diagnosed with NMOSD according to the International Panel for NMO Diagnosis 2015 criteria. The Beck Depression Inventory (BDI) was classified into severe, moderate, or minimal/no depressive state category. We used the Fatigue Severity Scale to evaluate fatigue. Scores from the Brief Pain Inventory and the PainDETECT Questionnaire were normalized to estimate neuropathic pain. Psychotropic, pain, and immunosuppressant medications were tabulated by established classes.Results: Twenty-eight percent of patients with NMOSD (n = 20) had BDI scores indicative of moderate or severe depression; 48% of patients (n = 34) endorsed significant levels of neuropathic pain. Severity of depression was moderately associated with neuropathic pain (r = 0.341, p < 0.004) but this relationship was confounded by levels of fatigue. Furthermore, only 40% of patients with moderate or severe depressive symptoms received antidepressant medical treatment. Fifty percent of those treated reported persistent moderate to severe depressive symptoms under treatment.Conclusions: Moderate and severe depression in patients with NMOSD is associated with neuropathic pain and fatigue and is insufficiently treated. These results are consistent across 2 research centers and continents. Future research needs to address how depression can be effectively managed and treated in NMOSD.AQP4=aquaporin-4; BDI=Beck Depression Inventory; BPI=Brief Pain Inventory; EDSS=Expanded Disability Status Scale; FSS=Fatigue Severity Scale; JHU=Johns Hopkins Hospital; NMO=neuromyelitis optica; NMOSD=neuromyelitis optica spectrum disorder; ON=optic neuritis; PDQ=PainDETECT Questionnaire; SNRI=serotonin norepinephrine reuptake inhibitor; SSRI=selective serotonin reuptake inhibitor; TM=transverse myelitis