RT Journal Article
SR Electronic
T1 Acute optic neuritis
JF Neurology - Neuroimmunology Neuroinflammation
JO Neurol Neuroimmunol Neuroinflamm
FD Lippincott Williams & Wilkins
SP e135
DO 10.1212/NXI.0000000000000135
VO 2
IS 4
A1 Galetta, Steven L.
A1 Villoslada, Pablo
A1 Levin, Netta
A1 Shindler, Kenneth
A1 Ishikawa, Hiroshi
A1 Parr, Edward
A1 Cadavid, Diego
A1 Balcer, Laura J.
YR 2015
UL http://nn.neurology.org/content/2/4/e135.abstract
AB Idiopathic demyelinating optic neuritis (ON) most commonly presents as acute unilateral vision loss and eye pain and is frequently associated with multiple sclerosis. Although emphasis is often placed on the good recovery of high-contrast visual acuity, persistent deficits are frequently observed in other aspects of vision, including contrast sensitivity, visual field testing, color vision, motion perception, and vision-related quality of life. Persistent and profound structural and functional changes are often revealed by imaging and electrophysiologic techniques, including optical coherence tomography, visual-evoked potentials, and nonconventional MRI. These abnormalities can impair patients' abilities to perform daily activities (e.g., driving, working) so they have important implications for patients' quality of life. In this article, we review the sequelae from ON, including clinical, structural, and functional changes and their interrelationships. The unmet needs in each of these areas are considered and the progress made toward meeting those needs is examined. Finally, we provide an overview of past and present investigational approaches for disease modification in ON.AD=axial diffusivity; DTI=diffusion tensor imaging; FA=fractional anisotropy; GCL=ganglion cell layer; IPL=inner plexiform layer; mfVEP=multifocal VEP; MS=multiple sclerosis; MSFC=Multiple Sclerosis Functional Composite; MT=magnetization transfer; NEI-VFQ-25=25-item National Eye Institute Visual Functioning Questionnaire; OCT=optical coherence tomography; ON=optic neuritis; ONTT=Optic Neuritis Treatment Trial; QOL=quality of life; RD=radial diffusivity; RGC=retinal ganglion cell; RGCL=retinal ganglion cell layer; RNFL=retinal nerve fiber layer; SD-OCT=spectral-domain OCT; SLCLA=Sloan low-contrast letter acuity; TD-OCT=time-domain OCT; VEP=visual-evoked potential