RT Journal Article
SR Electronic
T1 Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults
JF Neurology - Neuroimmunology Neuroinflammation
JO Neurol Neuroimmunol Neuroinflamm
FD Lippincott Williams & Wilkins
SP e521
DO 10.1212/NXI.0000000000000521
VO 6
IS 1
A1 Yian Gu
A1 Jose Gutierrez
A1 Irene B. Meier
A1 Vanessa A. Guzman
A1 Jennifer J. Manly
A1 Nicole Schupf
A1 Adam M. Brickman
A1 Richard Mayeux
YR 2019
UL http://nn.neurology.org/content/6/1/e521.abstract
AB Objective This investigation aimed at examining whether circulating inflammatory biomarkers C-reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin (ACT) were related to cerebrovascular disease (CVD) assessed by MRI.Methods The study included nondemented elderly participants of a community-based, multiethnic cohort, who received baseline MRI scans and had CRP (n = 508), ACT (435), and IL6 (N = 357) measured by ELISA. Silent brain infarcts and white matter hyperintensities (WMH) were derived from all available MRI scans at baseline, approximately 4.4 years after blood sample collection for inflammatory biomarkers. Repeated assessments of infarcts and WMH, as well as microbleeds assessment, were performed at follow-up MRI visits around 4.5 years later. Cross-sectional and longitudinal relationship between inflammatory biomarkers and CVD were analyzed using appropriate logistic regression models, generalized linear models, or COX models.Results After adjusting for age, sex, ethnicity, education, APOE genotype, and intracranial volume, 1 SD increase in log10IL6 was associated with infarcts on MRI {odds ratio [OR] (95% confidence interval [CI]) = 1.28 [1.02–1.60], p = 0.033}, and 1 SD increase in log10CRP and log10ACT was associated with microbleeds (OR [95% CI] = 1.46 [1.02–2.09], p = 0.041; and 1.65 [1.11–2.46], p = 0.013; respectively). One SD increase in log10ACT was also associated with larger WMH at the follow-up MRI (b = 0.103, p = 0.012) and increased accumulation of WMH volume (b = 0.062, p = 0.041) during follow-up. The associations remained significant after additional adjustment of vascular risk factors and excluding participants with clinical stroke.Conclusions Among older adults, increased circulating inflammatory biomarkers were associated with the presence of infarcts and microbleeds, WMH burden, and progression of WMH.ACT=alpha 1-antichymotrypsin; APOE=apolipoprotein; BMI=body mass index; CAA=cerebral amyloid angiopathy; CVD=cerebrovascular disease; CRP=C-reactive protein; CV=coefficient of variation; FOV=field of view; GRE=gradient echo; ICV=intracranial volume; IL6=interleukin-6; WHICAP=Washington Heights/Hamilton Heights Inwood Columbia Aging Project; WMH=white matter hyperintensity; sICAM-1=intercellular adhesion molecule-1